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Local Anestheic Pramoxine / Pramoxine hydrochloride / Pramoxine HCL CAS 637-58-1

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  Post Date: Nov 20,2017
  Expiry Date: Nov 20,2018
  Detailed Description: Cas No. :637-58-1 Quantity: 1000Kilograms
Specs:foil bag
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Local Anestheic Pramoxine / Pramoxine hydrochloride / Pramoxine HCL CAS 637-58-1

Basic info.


Product Name Pramoxine Hydrochloride
Synonyms 4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride ; gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride ; p-butoxyphenylgamma-morpholinopropyletherhydrochloride ; proctofoam ; Pramoxine HCL ; Praxomine Hydrochloride ; Tronothane Hydrochloride ; 4-[3-(P-BUTOXYPHENOXY)PROPYL]MORPHOLINE Hydrochloride ; 4-n-butoxyphenyl gamma-morpholinopropyl ether hydrochloride ; 4-N-BUTOXYPHENYL G-MORPHOLINOPROPYL ETHER Hydrochloride ; pramocaine Hydrochloride ; 4-[3-(4-butoxyphenoxy)propyl]morpholine Hydrochloride (1:1)
Molecular Formula C17H28ClNO3
Molecular Weight 329.8621
InChI InChI=1/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H
CAS Registry Number 637-58-1
EINECS 211-293-1
Boiling point 427°C at 760 mmHg
Flash point 123.5°C
Vapour Pressure 1.7E-07mmHg at 25°C



Description :

Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent

Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.


Application :

Pramoxine Hydrochloride are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.


COA:
Melting range 170~174°C 171.7~173.2°C
Loss on drying ≤1.0% 0.12%
Residue on ignition ≤0.1% 0.04%
Ethanol ≤0.5% 0.061%
Carbinol ≤0.3% 0.10%
Acetone ≤0.5% Not detected
Assay 98.0%~102.0% 99.98%


Usage:

Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.


Related Local Anesthetic APIs

local anaesthetics APLS CAS
Benzocaine CAS:94-09-7
Benzocaine Hydrochloride CAS:23239-88-5
Lidocaine Base CAS:137-58-6
Lidocaine Hydrochloride CAS:73-78-9
Procaine hydrochloride CAS:51-05-8
Procaine CAS 59-46-1
Tetracaine hydrochloride CAS:136-47-0
Tetracaine CAS: 94-24-6
Articaine hydrochloride CAS:23964-57-0
Articaine CAS:23964-58-1
Propitocaine hydrochloride CAS:1786-81-8
Prilocaine CAS:721-50-6
Levobupivacaine hydrochloride CAS:27262-48-2
Ropivacaine hydrochloride CAS:132112-35-7
Dibucaine hydrochloride CAS:61-12-1
Dibucaine CAS:85-79-0
Proparacaine hydrochloride CAS:5875-06-9
Bupivacaine hydrochloride CAS:14252-80-3
Isotretinoin (CAS:4759-48-2)
2,5-dimethoxyphenethylamine (CAS:3600-86-0)
Phenacetin (CAS:62-44-2)
Gama-Butyrolactone (GBL) (CAS:96-48-0)

  CAS Registry Number:

637-58-1

  Synonyms: ;4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride;gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride;p-butoxyphenylgamma-morpholinopropyletherhydrochloride;proctofoam;Pramoxine HCL;Praxomine Hydrochloride;Tronothane Hydrochloride;4-[3-(P-BUTOXYPHENOXY)PROPYL]MORPHOLINE Hydrochloride;4-n-butoxyphenyl gamma-morpholinopropyl ether hydrochloride;4-N-BUTOXYPHENYL G-MORPHOLINOPROPYL ETHER Hydrochloride;pramocaine Hydrochloride;4-[3-(4-butoxyphenoxy)propyl]morpholine Hydrochloride (1:1);
  Molecular Formula: C17H28ClNO3
  Molecular Weight: 329.8621
  Molecular Structure: 637-58-1 Pramoxine Hydrochloride
  Hazard Symbols:  Xi:Irritant;
  Risk Codes: R22:;
R36/37/38:;
  Safety Description: S26:;
S36:;

  Company: Hengyang Desen Biotechnology Co., Ltd.     [ China ]        
  Contact: Koala
  Tel: +86-073-48164621
  Fax: 027-88608190-722
  Email: koala@desen-nutrition.com
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