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Losartan Potassium CAS NO: 124750-99-8

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  Post Date: Nov 11,2024
  Expiry Date: May 10,2025
  Detailed Description: Cas No. :124750-99-8 Payment Method: LC/TT
Losartan Potassium:
CAS NO: 124750-99-8
Standard: Enterprise Standard
Package: 25kg/barrel
Molecular Formula: C22H22ClKN6O
Molecular Weight: 461.01
Description:
Application:
Assay: ‰¥98.0%

Description:
Losartan is a specific antagonist of the angiotensin II receptor type AT1; it does not inhibit ACE (kininase II), the enzyme that degrades bradykinin. Removal of angiotensin II negative feed back on renin secretion leads to increased plasma renin activity, during losartan administration. A 2 to 3-fold increase in angiotensin II in plasma comes as a result of increases in plasma renin activity. However, antihypertensive activity and suppression of plasma aldosterone concentration are apparent, indicating effective angiotensin II receptor blockade. After discontinuation of losartan, plasma renin activity and angiotensin levels declined.


Specification:

Test Items Standard Result
Description A white or off- white powder white powder
Identification IR,UV,test for potassium Conforms
Water ≤0.5% 0.3%
Any impurity ≤0.2% 0.07%
Total impurity ≤0.5% 0.10%
Heavy metals ≤10ppm ＜10ppm
Assay 98.5%-101.0% 99.9%
Residual solvents
cyclohexane ≤1000ppm 92ppm
Isopropyl alcohol ≤2000ppm 321ppm
Conclusion The results conform with USP29 standard
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  CAS Registry Number:

124750-99-8
  Synonyms: ;potassium 5-(4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}biphenyl-2-yl)tetrazol-1-ide;potassium (2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanolate;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt;
  Molecular Formula: C22H22ClKN6O
  Molecular Weight: 461.001
  Molecular Structure: 124750-99-8 Losartan Potassium

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