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Metformin HCL

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  Post Date: Dec 24,2016
  Expiry Date: Jun 22,2017
  Detailed Description: Cas No. :1115-70-4 Metformin HCL

Metformin Hydrochloride; 3-(diaminomethylidene)-1,1-dimethylguanidine hydrochloride (1:1)

CAS NO.:1115-70-4
EINECS: 214-230-6

Formula:C4H12ClN5

Molecular Weight:165.6246

Melting Point:220 ~ 225 ℃.

Appearance: white crystalline powder; odorless. soluble in water, dissolved in methanol, slightly soluble in ethanol, insoluble in chloroform or ether.
Absorption coefficient of this product, accurately weighed, dissolved in water and diluted quantitatively per 1ml solution containing 5μg. According to the spectrophotometric determination of absorbance at 233nm wavelength, the absorption coefficient of 778 ~ 818


.Metformin hydrochloride is a biguanide oral hypoglycemic agents , also known as metformin hydrochloride , Glucophage , United Dikang , hypoglycemic effect is weaker than phenformin , the main role is to reduce the A cell glucagon secretion , promote the conversion of glucose to glycogen , has not stimulate insulin secretion from pancreatic β- cell characteristics .
Hypoglycemic mechanism is as follows:
1 . Increase the sensitivity of peripheral tissues to insulin , increased insulin -mediated glucose utilization .
2 glucose utilization increase in non -insulin-dependent tissues such as brain, blood cells , kidney medulla , intestine, skin and so on.
3 hepatic gluconeogenesis inhibition effect, reducing hepatic glucose output .
4 inhibited intestinal cell uptake of glucose .
5 Inhibition of cholesterol biosynthesis and storage, reduce blood triglyceride and total cholesterol levels.
Clinically metformin hydrochloride for the treatment of simple diet control are not satisfied with type Ⅱ diabetes patients, especially with obesity and hyperinsulinemia who use the drug not only hypoglycemic effect, may also have to reduce the weight and hyperinsulinemia effect. For some sulfonylureas may be effective in patients with poor efficacy , such as the sulfonylureas , intestinal glucosidase inhibitors or thiazolidinediones , TZDs hypoglycemic drugs , were better than the results alone . Can also be used in patients with insulin therapy to reduce the amount of insulin

ivy8888@chembj.com

  CAS Registry Number:

1115-70-4

  Synonyms: ;Metformin Hydrochloride;3-(diaminomethylidene)-1,1-dimethylguanidine hydrochloride (1:1);1,1-dimethylbiguanide hydrochloride;
  Molecular Formula: C4H12ClN5
  Molecular Weight: 165.6246
  Molecular Structure: 1115-70-4 Metformin HCL
  Hazard Symbols:  Xn:Harmful;
  Risk Codes: R22:;
R36/38:;
  Safety Description: S26:;
S36:;

  Company: Wuhan Yuancheng Gongchuang Tech. Co.,Ltd.     [ China ]        
  Contact: Melody Qiu
  Tel: 86-027088217383
  Fax:
  Email: ivy8888@chembj.com
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