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Mitiglinide calcium

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  Post Date: Jan 09,2018
  Expiry Date: Jul 08,2018
  Detailed Description: Cas No. :207844-01-7 Quantity: mass in stockKilograms
Specs:white powder
Price:negotiable USD Kilograms
Payment Method: T/T, Western Union,Moneygram and Bitcoin.
Description

Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.


Pharmacodynamics

Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs. It is approved for use in Japan but has not yet gained FDA approval.



Mechanism of action

Mitiglinide is thought to stimulate insulin secretion by binding to and blocking ATP-sensitive K(+) (K(ATP)) channels (Kir6.2/SUR1 complex, KATP channels) in pancreatic beta-cells. Closure of potassium channels causes depolarization which stimulates calcium influx through voltage-gated calcium channels. High intracellular calcium subsequently triggers the exocytosis of insulin granules.

  CAS Registry Number:

207844-01-7
  Synonyms: ;(S)-2-Benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)butyric acid calcium salt dihydrate; (aS,3aR,7aS)-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid calcium salt dihydrate;Calcium Mitiglinide dihydrate;2H-isoindole-2-butanoic acid, octahydro-γ-oxo-α-(phenylmethyl)-, (alphaS,3aR,7aS)-, calcium salt, monohydrate;
  Molecular Formula: C19H27CaNO4
  Molecular Weight: 373.4989
  Molecular Structure: 207844-01-7 Mitiglinide Calcium dihydrate

  Company: Hengyang Desen Biotechnology Co., Ltd.     [ China ]        
  Contact: ava
  Tel: 86-18908446905
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