Native Bovine Deoxyribonuclease I
| Post Date: |
May 21,2024 |
| Expiry Date: |
Nov 17,2024 |
| Detailed Description: |
Cas No. :9003-98-9
DNase I is an endonuclease that acts on phosphodiester bonds adjacent to pyrimidines to produce polynucleotides with terminal 5′-phosphates. In the presence of Mg2+, DNAse I cleaves each strand of DNA independently and the cleavage sites are random. Both DNA strands are cleaved at approximately the same site in the presence of Mn2+.2 The pH optimum is found to be between 7 and 8. Divalent cations such as Mn2+, Ca2+, Co2+, and Zn2+ are activators of the enzyme.3 A concentration of 5 mM Ca2+ stabilizes the enzyme against proteolytic digestion. DNAse I from bovine pancreas consists of four chromatographically distinguishable components, A, B, C, and D, with molar ratios being 4:1:1 respectively. Only minor amounts of D are found.4 2-Mercaptoethanol, chelators, sodium dodecyl sulfate (SDS)5 and actin6 are known to inhibit the enzyme activity. https://www.creative-enzymes.com/product/Native-Bovine-Deoxyribonuclease-I_1725.html
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| CAS Registry Number: |
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| Synonyms: |
;Deoxyribonuclease I, Bovine Pancreas;Deoxyribonuclease I from bovine pancreas;deoxyribonuclease I type ii-S from*bovine pancrea;deoxyribonuclease I crude*lyophilized powder;Deoxyribonuclease;Deoxyribonuclease I; |
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