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Norfloxacin Hydrochloride(toni@ycgmp.com)

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  Post Date: Jun 25,2015
  Expiry Date: Jun 24,2016
  Detailed Description: Cas No. :104142-93-0 Payment Method: T/T
Norfloxacin Hydrochloride
Chemical Name: Desethylene Norfloxacin Hydrochloride
CAS: 104142-93-0
MF: C16H19ClFN3O3
MW: 355.79
Appearance: White to light yellow crystalline powder
Synonyms: Norfloxacin hydrochloride;1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride
CBNumber: CB91477620

Molecular Weight 319.33

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Alternate names MK-366, Baccidal Barazan, Chibroxine,

Toxicity and Hazards Due to the potential danger associated with the use of some of United States Biological biochemicals, all products should be handled by qualified personnel only, trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many experimental compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any and all chemicals lies with the user. All goods sold by United States Biological carry the condition that liability for any injury, loss or damage whatsoever to persons or real property resulting from the handling of the said goods lies with the user. Acceptance of our goods binds the customer to these terms

Specifications

Norfloxacin is a synthetic chemotherapeutic agent occasionally used to treat common as well as complicated urinary tract infections. It is sold under various brand names with the most common being Noroxin. In form of ophthalmic solutions it is known as Chibroxin. Norfloxacin is a second generation synthetic fluoroquinolone (quinolone) developed by Kyorin Seiyaku K.K. (Kyorin).

Catalog # N4000-10
The licensed uses for norfloxacin are quite limited as norfloxacin is to be considered a drug of last resort when all other antibiotics have failed. There are currently only three approved uses in the adult population[5] (one of which is restricted[6]) and the other ineffective due to bacterial resistance. Chibroxin[7] (ophthalmic) is approved for use in children older than one year of age. Norfloxacin interacts with a number of other drugs, as well as a number of herbal and natural supplements. Such interactions increase the risk of anticoagulation and the formation of non-absorbable complexes, as well as increasing the risk of toxicity.[8]
Norfloxacin is associated with a number of serious and life threatening adverse reactions as well as spontaneous tendon ruptures and irreversible peripheral neuropathy. Such reactions may manifest long after therapy had been completed and in severe cases may result in life long disabilities. Hepatoxicity resulting in fatalities has also been reported with the use of norfloxacin.

Melting Point 210-211°C

Solubility DMSO, Methanol (sparingly)

Method for determining Identity Proton NMR Spectroscopic Analysis

TLC Conditions SiO2; Methanol: NH4OH; 9:1; Visualized with UV and AMCS; Single spot; Rf=0.3

Storage and Stability May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

  CAS Registry Number:

104142-93-0

  Synonyms: ;1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride;1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;Norfloxacin HCL;
  Molecular Formula: C16H19ClFN3O3
  Molecular Weight: 355.7918
  Molecular Structure: 104142-93-0 Norfloxacin hydrochloride

  Company: Hulumimi Pharmaceuticals     [ China ]        
  Contact: Toni Zhong
  Tel: 027-50756080
  Fax: 0086-27-88048077-794
  Email: toni@ycgmp.com
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