Olaparib
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| Post Date: | Jan 09,2018 |
| Expiry Date: | Jul 08,2018 |
| Detailed Description: |
Cas No. :763113-22-0
Quantity: mass in stockKilograms Specs:white powder Price:negotiable USD Kilograms Payment Method: T/T, Western Union,Moneygram and Bitcoin. Description Lynparza is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. PARP enzymes are involved in normal cellular homeostasis, including DNA transcription, cell cycle regulation, and DNA repair. Olaparib may inhibit growth of select tumor cell lines in vitro and decrease tumor growth in mouse xenograft models of human cancer both as monotherapy or following platinum-based chemotherapy. Increased cytotoxicity and anti-tumor activity following treatment with olaparib were noted in cell lines and mouse tumor models with deficiencies in BRCA. In vitro studies have shown that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complex, causing disruption of cellular homeostasis and cell death. Application Ovarian cancer forms in the ovary, one of a pair of female reproductive glands where ova, or eggs, are formed. Lynparza is really a poly ADP-ribose polymerase (PARP) inhibitor that blocks enzymes linked to repairing damaged DNA. It is intended for women with heavily pretreated ovarian cancer which is associated with defective BRCA genes. "Today's approval constitutes the initial of a new form of drugs for treating ovarian cancer," said Richard Pazdur, MD, director of the Office of Hematology and Oncology Products within the FDA's Center for Drug Evaluation and Research. "Lynparza qualifies for patients with specific abnormalities within the BRCA gene and is an example of the way a greater understanding of the underlying mechanisms of disease can cause targeted, more personalized |
| CAS Registry Number: | 763113-22-0 |
| Synonyms: | ;4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one;AZD2281;1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine; |
| Molecular Formula: | C24H23FN4O3 |
| Molecular Weight: | 434.4628 |
| Molecular Structure: | 
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| Company: | Hengyang Desen Biotechnology Co., Ltd. [ China ] |
| Contact: | ava |
| Tel: | 86-18908446905 |
| Fax: | |
| Email: | ava@ycgmp.com |
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