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Pentadecapeptide BPC 157 2mg/vial

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  Post Date: Jun 25,2015
  Expiry Date: Jun 24,2016
  Detailed Description: Cas No. :toni@ycgmp.com pentadecapeptide BPC 157 2mg/vial

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC)

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice.

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration

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Abstract

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay. However, the survival of BPC 157-treated cells was significantly increased under the H2O2 stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.

nbsp;was responsible for pituitary stimulation. In 1999 researchers Goa and Prakash checked sermorelin GH as provocative tasting method for deficiency of endogenous G-hormone.
The most known features of this research compound are increasing lean muscular tissue mass, reducing fat, increasing bone tissue density and even enhancing functioning of immune system. It complies with certain amino-segment of natural long-chained GHrh. Sermorelin helps to convert exceeded volume of GH by liver into IGF-1.

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Product Tags: pentadecapeptide BPC 157 2mg/vial

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email adress : toni at ycgmp dot com
Tel:86-18872220727

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toni@ycgmp.com

  Company: Hulumimi Pharmaceuticals     [ China ]        
  Contact: Toni Zhong
  Tel: 86-18872220727
  Fax: 0086-27-88048077-794
  Email: toni@ycgmp.com
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