Pioglitazone hydrochloride
Inquiry
| Post Date: | Mar 06,2015 |
| Expiry Date: | Sep 02,2015 |
| Detailed Description: |
Cas No. :112529-15-4
Quantity: 1Kilograms Price:1 USD Metric Tons Payment Method: Western union, money gram, T/T Pioglitazone hydrochloride Synonyms: Pioglitazone HCl; 5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide; Pioglitazone N-Oxide; 5-{4-[2-(5-ethyl-1-oxidopyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione; 5-[[4-2-(5-ethyl-2-pyridinyl)ethoxy]benzylidene]-2,4-thiazolidinedione Hydrochloride CAS: 112529-15-4 MF: C19H21ClN2O3S MW: 392.9 Assay: 98.5% Appearance: White crystalline powder Property: Pioglitazone and rosiglitazone is at present the clinical treatment of diabetes common thiazolidine two ketones anti diabetes drugs, belonging to the insulin sensitizing agent. Can reduce the peripheral tissue and hepatic insulin resistance, increase insulin dependent glucose, and decrease hepatic glucose output. Pharmacological effects: 1. pioglitazone through direct reduce insulin resistance and improve the beta cell function to control blood glucose and lasting. Pioglitazone is a highly selective and very powerful effect of peroxisome proliferator activated receptor gamma (PPAR γ) agonist. The receptor is a protein found in insulin sensitive tissue, fat, skeletal muscle and liver tissue. 2. pioglitazone can reduce hyperinsulinemia and plasma free fatty acid level. Lower plasma insulin levels suggest that pioglitazone can reduce the burden of pancreatic beta cells. Since the level of free fatty acids of high toxic effect on the pancreas, thus reducing the level of free fatty acids also have protective effect on pancreatic beta cell function. Therefore, the basic physiological aspects of type 2 diabetes to reduce insulin resistance, improved beta cell function to control blood glucose. Usage: 1. mainly applicable to 1 of pioglitazone on diet and exercise can not control the blood glucose in non insulin dependent diabetes mellitus (NIDDM) patients. Can treatment alone or with a sulfonylurea, metformin and insulin treatment. 2. clinical study showed that pioglitazone can improve the insulin resistance, insulin sensitivity, improve the insulin response to cell, and improve glucose homeostasis disorder. In the clinical trials, pioglitazone, metformin and sulfonylurea or insulin, can enhance the curative effect. Packing: 1kg/bag |
| CAS Registry Number: | 112529-15-4 |
| Synonyms: | ;Pioglitazone HCl;5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide;Pioglitazone N-Oxide;5-{4-[2-(5-ethyl-1-oxidopyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione;5-[[4-2-(5-ethyl-2-pyridinyl)ethoxy]benzylidene]-2,4-thiazolidinedione Hydrochloride;[5-[[4-[2-(5-Ethyl-2-Pyridinyl)Ethoxy]Phenyl]Methyl]-2,4-] Thiazolidinedione Hydrochloride; |
| Molecular Formula: | C19H20N2O3S·HCl |
| Molecular Weight: | 392.90 |
| Molecular Structure: | 
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| Company: | Hubei Yuancheng Pharmaceutical Co.,Ltd [ China ] |
| Contact: | Kelly |
| Tel: | +86-27-50755978 |
| Fax: | +86-27-68886696 |
| Email: | yckelly@yccreate.com |
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