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Polypeptides Mt-2/Mt-II/Melanotan-II CAS: 121062-08-6 For Fat Burning
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| Post Date: | Mar 23,2017 |
| Expiry Date: | Mar 23,2018 |
| Detailed Description: |
Cas No. :121062-08-6
Quantity: 1000Kilograms Specs:white powder Price:10 USD Kilograms Payment Method: T/T,Western Union,Moneygram, Melanotan II (MT-2) Description Melanotan II is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction, Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties. Melanotan 2 Tanning Injections (otherwise known as MT2) was first synthesized at the University of Arizona. Researches there knew that onc of the best defenses against skin cancer was melanin activated in the skin, a tan. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure. The body's naturally occuring hormone MSH causes melanogenesis, a process by which the skin's pigment cells (melanocytes) produce the skin's pigment (melanin). They tested to see if administering this endogenous hormone to the body directly could be an effective method to cause sunless tanning. What they found was that while it appeared to work, natural MSH had too short a half life in the body to be practical as a therapeutic drug. So they decided to find a more potent and stable alternative, one that would be more practical. After synthesizing and screening hundreds of molecules, the researchers headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7] MSH, that was approimately 1,000 times more potent than the natural MSH. They dubbed this new peptide molecule, "Melanotan" (later Melanotan-1, now know as afamelanotide). They subsequently developed another analog, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2), which they called "Melanotan" Tanning Injections. The scientists hoped to use these peptides to combat melanoma by stimulating the body's natural pigmentary mechanism to create a tan without first needing exposure to harmful levels of UV radiation. This in turn, they hypothesized, could reduce the potential for skin damage that can eventually lead to skin cancer. A pilot phase I clinical trial conducted on three males by the College of Medacine, Pharmacology Department, University of Arizona in Tuscon, Arizona pulished in 1996 reported that, "Melanotan" Tanning Injections has tanning activity in humans given only 5 low doses every other day by subcutaneous injection." The side effects reported were mild nausea and a "stretching and yawning complex" that correlated with spontaneous penile erections. The Department of Pharmacology, University of Arizona College of Medacin published in 1998 that involved 10 men who suffered from psychogenic erectile dysfunction. Their trial concluded that, "Melanotan" Tanning Injections is a potent initiator of erections in men with pyschogenic erectile dydfunction and has manageable side effects at a dose of 0.025mg/kg. A clinical study published in 2000 of 20 men with psychogenic and organic erectile dysfunction conducted at the Section of Urology of The University of Arizona College of Medacin concluded, "that Melanotan II Tanning Injections is a potent initiator of penile erection in men with ecrectile dysfunction. Melanotan 2 Spec. Alias:Melanotan 2, Melanotan, Mt II, Melanotan 2 (MT2)Melanotan-II CAS 121062-08-6 Purity (by HPLC): 99.00% Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 Molecular Formula: C50H69N15O9 Molecular weight: 1024.2 Appreance:White Powder Price:Factory price(Negociable) Packing:Discreet and Disguised packing to pass the customs. Storage Condition; away from light, cold storage (2-8 degree) Usage:Keeping Health and Promoting Growth. prevention sunlight-induce skin cancer; Sexual Dysfunction & Fat Decomposition. Promoting skin tanning. protecting against the harmful effects of ultraviolet radiation from sunlight. Standard:Medicine Grade |
| CAS Registry Number: | 121062-08-6 |
| Synonyms: | ;Melanotan II;Melanotanâ…ˇ Acetate;N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide (2->7)-lactam;Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2;Ac-[Nle4,Asp5,D-Phe7,Lys10]alpha-MSH-(4-10)-NH2;Melanotanâ…ˇ;(3S,6S,9R,12S,15S,23S)-15-[(N-acetyl-L-norleucyl)amino]-9-benzyl-6-{3-[(diaminomethylidene)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide;N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-N~5~-(diaminomethylidene)-L-ornithyl-L-tryptophyl-L-lysinamide;Melanotan-II;MT-II;MTII, Melanotan II; |
| Molecular Formula: | C50H71N15O10 |
| Molecular Weight: | 1042.1932 |
| Molecular Structure: | 
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| Company: | China yuancheng technoloty wuhan branch ltd. [ China ] |
| Contact: | Kathelin |
| Tel: | 86-27-6888669 |
| Fax: | |
| Email: | kathelin@chembj.com |
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