Posaconazole
Inquiry
| Post Date: | Oct 20,2021 |
| Expiry Date: | Oct 20,2022 |
| Detailed Description: |
Cas No. :171228-49-2
No.： CPTA011
Products： Posaconazole Synonyms： 4-(4-(4-(4-(((3R,5R)-5-(3,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one Cas No.： 171228-49-2 Molecular Formula： C37H42F2N8O4 Molecular Weight： 700.78 Assay： ＞99.7% Usage： broad-spectrum antibiotic Molecular Structure： Posaconazole (posaconazole) is a derivative of the itraconazole, listed in 2007, the second generation of the three azole antifungal drugs. Broad antibacterial spectrum, for candida, histoplasma capsulatum and plug, sickle spore bacteria, bipolar bacteria zygomycete fungi bacteria and yeast. Including resistance to fluconazole than white beads strains, cryptococcus neoformans and aspergillus has a strong inhibitory activity; Particularly for rare, but life-threatening fungal disease (zygomycosis, sickle disease and coccidioidomycosis, etc.) is effective. Process of the body This drug is poorly soluble in water, at present only oral suspension agent, on an empty stomach or after meal oral, respectively, in 3 ~ 4 ~ 10 h and 4 h reached peak blood drug concentration. Plasma protein binding is as high as 98.2%, mainly combined with albumin. Apparent volume of distribution, on average, as high as 1744 l, highly tissue penetration. Can through the placental barrier and is secreted in the breast milk. Clinical application of This product is applicable to variety of amphotericin intolerance or refractory adult treatment of invasive fungal infections; The high risk |
| CAS Registry Number: | 171228-49-2 |
| Synonyms: | ;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;Sch 56592;4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one;HYDROXYPROPYL]-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE;Posaconazole for research;NOXAFIL;(2xi)-1,4-anhydro-2,3,5-trideoxy-4-(2,4-difluorophenyl)-2-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-5-(1H-1,2,4-triazol-1-yl)-D-glycero-pentitol; |
| Molecular Formula: | C37H42F2N8O4 |
| Molecular Weight: | 700.7774 |
| Molecular Structure: | 
|
| Company: | Tianjin Chempharmatech Co.,Ltd. [ China ] |
| Contact: | Emy |
| Tel: | +86-022-66211079 |
| Fax: | +86-022-66211179 |
| Email: | wuzhanyuan@chempharmatech.com |
-
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.
