Home > Offer to Sell > Intermediates > Pharmaceutical intermediates > Pramoxine

Pramoxine

Inquiry
  Post Date: Nov 25,2024
  Expiry Date: May 24,2025
  Detailed Description: Cas No. :637-58-1 Quantity: 20Metric Tons
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953[1] and used as an antipruritic. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent.[1] Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans.[1] Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.
Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches.[2] The popular itch creams Gold Bond and some forms of calamine lotion use pramocaine hydrochloride to numb sensitive skin, as does the pain relief variant of Neosporin and some formulations of Sarna. The hydrochloride salt form of pramocaine is water-soluble.
Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.

  CAS Registry Number:

637-58-1
  Synonyms: ;4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride;gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride;p-butoxyphenylgamma-morpholinopropyletherhydrochloride;proctofoam;Pramoxine HCL;Praxomine Hydrochloride;Tronothane Hydrochloride;4-[3-(P-BUTOXYPHENOXY)PROPYL]MORPHOLINE Hydrochloride;4-n-butoxyphenyl gamma-morpholinopropyl ether hydrochloride;4-N-BUTOXYPHENYL G-MORPHOLINOPROPYL ETHER Hydrochloride;pramocaine Hydrochloride;4-[3-(4-butoxyphenoxy)propyl]morpholine Hydrochloride (1:1);
  Molecular Formula: C17H28ClNO3
  Molecular Weight: 329.8621
  Molecular Structure: 637-58-1 Pramoxine Hydrochloride
  Hazard Symbols:  Xi:Irritant;
  Risk Codes: R22:;
R36/37/38:;
  Safety Description: S26:;
S36:;

  Company: Shandong Chenghui Shuangda Pharmaceutical Co., Ltd.     [ China ]          
  Contact: Kathy Qian
  Tel: 0531-58897098
  Fax: 0531-58897093
  Email: info@jnchsd.com
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.