Home > Offer to Sell > Pharmaceuticals and Biochemicals > Auxiliaries and miscellaneous medicinal chemicals > Priligy, Dapoxetine for Delaying Ejaculation PE Treatment (CAS: 129938-20-1)

Priligy, Dapoxetine for Delaying Ejaculation PE Treatment (CAS: 129938-20-1)

Inquiry
  Post Date: Apr 29,2015
  Expiry Date: Apr 28,2016
  Detailed Description: Cas No. :129938-20-1 Quantity: 1000Kilograms
Specs:SGS
Price:1 USD Kilograms
Payment Method: T/T,Western Union,Money Gram
Detailed Product Description


Dapoxetine
Alias: Priligy

English Synonyms: DAPOXETIN; DAPOXETINE; (S-(+)-N, N-Dimethyl-a-[2-(naphthalenyloxy)ethyl]benzenemethanamine hydrochloride; Dapoxetine hydrochloride

CAS No: 129938-20-1


Assay: 98%

Molecular Formula: C21H23NO HCL

Molecular Weight: 341.88

Packing: 1kg/ Foil Bag

Appearance: White powder, odorless, slightly sweet, soluble in water and alcohol. Can be made into tablets, beverages, wine, capsules and other dosage forms

USES: Treat male premature ejaculation and erectile dysfunction.

Applications:

Dapoxetine, marketed as Priligy (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18-64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.


Treat male premature ejaculation and erectile dysfunction.
Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger's meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug's accumulation in the body, and therefore reducing side effects.


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Name Dapoxetine / Priligy
CAS No. 129938-20-1
ITEMS
STANDARD
RESULTS

Characteristics
White or almost white crystalline powder
White crystalline powder

Melting point
175.0~177.0°C
174.0~179.0°C

Specific rotatlon
+128°±3(C=1,CH3OH)
+128°±3(C=1,CH3OH)

Loss on drying
≤0.5%
0.32%

Heavy metals
0ppm
0ppm

Relative substance
≤0.1%
Total impurity
0.07%

Assay(on drled basis)
≥99.5%
99.61%

Conclusion
It complies to prescrlbed enterprise standard



  CAS Registry Number:

129938-20-1

  Synonyms: ;DAPOXETINE HCL;Rimonabant 75000;LY-21044;((S)-(+)-N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride);(S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride;(1S)-N,N-Dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride;(S)-n,n-dimethyl-3-(naphthalene-1-yloxy)-1-phenylpropan-1-amine hydrochloride;(S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride;(S-(+)-N,N-Dimethyl-a-[2-(naphthalenyloxy)ethyl]benzenemethanamine hydrochloride;N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride (1:1);DL-Dapoxteine HCL;Hydrochloric acid Dapoxetine;S-Dapoxetine hydrochloride;D-Dapoxetine HCL;D-Dapoxetine Hydrochloride;
  Molecular Formula: C21H24ClNO
  Molecular Weight: 341.8744
  Molecular Structure: 129938-20-1 Dapoxetine hydrochloride

  Company: Hubei Yuancheng Saichuang Technology Co., Ltd.     [ China ]        
  Contact: Jeffy ding
  Tel: +86-027-50756254
  Fax: +86-027-68886696
  Email: jeffy@ycphar.com
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