Product Name: L-Leucine
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| Post Date: | May 14,2013 |
| Expiry Date: | Nov 10,2013 |
| Detailed Description: |
Cas No. :CAS: 61-90-5
Specs:zc07@yccreate.com Payment Method: T/T,L/C Product Name: L-Leucine Another Name:(S)-2-Amino-4-methylpentanoic acid CAS: 61-90-5 Molecular Weight:131.17 Molecular Formula:C6H13NO2 Help edit Baike card L-leucine, also known as leucine The chemical name a amino isocaproate, 1819 Proust first isolated from the cheese, and later Braconnot get its crystalline acid hydrolysates from muscle and wool, and named bright acid. L-leucine is in one of the common 18 amino acids, the human body is one of the eight essential amino acids, in addition, due to the L-leucine and L-isoleucine, L-Screenshots acid, the molecular structure contains a methyl side chain is referred to as the branched chain amino acid (Branched chain Amina Acids BCAA). Directory Basic information Physical and chemical properties L-leucine production methods Use Edit this paragraph the basic information Chinese name: L-leucine Chinese alias: L-leucine; L-2-amino-4 - methyl-pentanoic acid [1] English name: L-Leucine English alias: (S)-2-Amino-4-methylpentanoic acid; L-Leucine 99 +%; H-Leu-OH; L-Leu; L (+) LEUCINE CAS :61-90-5 EINECS :200-522-0 MF: C6H13NO2 Molecular Weight: 131.17 Edit this paragraph physicochemical properties of L-leucine Formula C6H1302N relative molecular weight of 131.18, and the molecular structure: L a bright acid as a white crystal or crystalline powder, is a non-polar amino acids, slightly bitter taste, soluble in water, 20 ℃, 25 ℃ solubility, respectively, for 23. 7g / L and 24. 26g / L, and acetic acid (10.9g / L), dilute hydrochloric acid, an alkali solution and carbonate solution, slightly soluble in alcohol (0. 72g / L), insoluble in ether, heated to 145 ^ r 148 ° C sublimation decomposition ,293-295 0C The specific gravity 1. 29 (180C), specific optical rotation [a] D20 to +14 5 ^ - +16. 0 (6mo1 / L HCl, C = 1), and an isoelectric point of 5.98. Edit this paragraph method for producing amino acid L-leucine for producing hydrolyzed proteins from 1820. Extraction order L-cystine, L-histidine, L-Leucine, L-arginine, in 1908, the Japanese Ikeda sodium glutamate is a flavor enhancer, began the industrial production History of amino acids. In 1957, Japan began the use of microorganisms glutamic acid fermentation production the fermentation method since opened a new chapter in the history of the production of amino acids. 1960s about L-leucine biosynthesis, and metabolic regulation mechanisms have been elucidated. Directed breeding and enzymatic production of L-leucine L-leucine [2] provides a theoretical basis for microbial fermentation production. L-leucine production methods are extraction, chemical synthesis, enzymatic method, and microbial fermentation. Method (protein hydrolysis method): amino acid is the composition of the protein was extracted under acidic conditions, the higher the content of the L-leucine protein hydrolysis, to obtain a mixture of various amino acids were separated and purified, refined processes to obtain L - leucine Product. Chemical synthesis: leucine chemical synthesis A. Strecker,. A halogenated acid ammonia solution, phase transfer catalysis several methods. Although chemical synthesis principle is simple, inexpensive, but the complexity of the operation, harsh reaction conditions, multi-product, the yield is not high, and some methods related to toxic substances. The chemical synthesis leucine racemic DL-leucine, in order to obtain a L-leucine, the need for the split of the optical isomers. Enzymatic method for producing L-leucine aminotransferase aminotransferase to. Of a keto isocaproate generate L-leucine. The related enzyme and NADH are covalently bound to the membrane, the substrate slowly through the membrane and the enzyme catalyzed reaction of L-leucine. 1981 is able to be lifted and the lifting effect. Obtain the mutant strain of the accumulation of desired product most effective method of releasing microorganisms through genetic mutations of normal metabolic control. Obtain mutant strains of several commonly used methods are as follows: Breeding auxotrophic strain, cut off or change the parallel metabolic pathways; Breeding anti-structural analogs mutants release of feedback inhibition and repression; Breeding membrane permeability mutants, so that the desired product excreted outside the cells, so that cells within the final product concentration may reach to cause the concentration of the feedback regulation; application of genetic engineering, the metabolic engineering means purpose modified microorganism strain, its high concentration of synthetic object product. Characteristics: white gloss hexahedral crystals or white crystalline powder. Slightly bitter taste. Sublimation at 145 ~ 148 ℃. M.p. 293 to 295 ° C (decomposition). In the presence of hydrocarbons in an aqueous solution of an inorganic acid in stable performance. Dissolved in 40ml of water and about 100ml acetate per gram. Slightly soluble in ethanol, soluble in dilute hydrochloric acid and alkaline hydroxide and carbonate solution. Insoluble in ether. Natural materials found in the spleen, heart, and exists in the form of a protein in a variety of animal and plant tissue decomposition corruption free out. Uses: Nutritional supplements. Generally used for bread and bakery products. Preparation of amino acid infusion and amino acid preparations, hypoglycemic agents, plant growth promoter. Used as a spice, can improve the flavor of food. Quality Standard: FCC Project criteria: Specific rotation +14.5 ~ +16.5 ° 98.5 to 101.5% Heavy metals (Pb) ≤ 0.002% Lead ≤ 10mg/kg Loss on drying ≤ 0.2% Chloride ≤ 0.1% Function: part of the essential amino acid requirements for adult men 2.2 g / d. Normal growth of infants and young children and adults to maintain normal nitrogen balance necessary. Limited: 1 accounted for 6.4% of the total protein in food. 2 can be safely used in food. [Packaging]: kraft paper bag or paper drum bag (barrel) net content of 25kg, and can also be packaged according to user needs. [Transport]: light loading and unloading to prevent damaged packaging, anti-sun and rain, can not be toxic pest gay movement. Non-dangerous goods. [Storage]: This product should be stored in a cool, dry, clean, shading environment, do not mix with the toxic and hazardous substances, in order to avoid contamination. The characteristics of L-leucine White gloss hexahedral crystals or white crystalline powder. Slightly bitter taste. Sublimation at 145 ~ 148 ℃. M.p. 293 to 295 ° C (decomposition). In the presence of hydrocarbons in an aqueous solution of an inorganic acid in stable performance. Dissolved in 40ml of water and about 100ml acetate per gram. Slightly soluble in ethanol, soluble in dilute hydrochloric acid and alkaline hydroxide and carbonate solution. Insoluble in ether. [3] Production of L-leucine A. Concentrated segment Raw materials: steam The time the mother liquor pass into the concentrate tank, pass into the steam temperature of 120 degrees, pressure-0.09Mpa concentrated time 6h, crystallization. End product: crystalline liquid (go and above) Time and segment Accessories: sulfuric acid, pure water Crystalline liquid to enter the time in the tank, pass into sulfuric acid, pure water, temperature 80, and 4h, filtered The end of product: 1, the filtrate (recycling), residues (ammonolysis segment go) Third, aminolysis Section Accessories: ammonia water, pure water, steam Residue enters the ammonia solution tank, pass into the aqueous ammonia, pure water, steam, temperature 80, the ammonolyzed time 3h, filtered Endpoint product, a filtrate (recycling) the residue (go decolorization segment) (cystine) IV decolorization segment. Accessories: steam, pure water, activated carbon Residue into the decolorizing cans pass (voted) into the steam, pure water, activated carbon, temperature 80, decolorization time 2h, filtered, The end of the product: 1, residues (recycling), filtrate (go to secondary and above) Five secondary and segment Accessories: ammonia, steam Filtrate into the secondary in the tank, pass into ammonia, steam, temperature 80, and 4h, filtered, Endpoint product, a filtrate (recycling) 2, residues (i.e. L-leucine crude product, to the refining section) Sixth, refining section Excipients: distilled water, steam (histidine hydrochloride) The last step and centrifugal drying rinsed with distilled water, fed into the dryer and pass into the steam drying, packaging, storage, drying temperature, drying time of 3H. Endpoint product: L-leucine finished Edit this section uses are essential amino acids, an adult male requirement 2.2g / d, to maintain normal nitrogen balance necessary for the baby normal growth and adult. This product as a nutritional supplement, formulated amino acid infusion and amino acid preparations, hypoglycemic agents, plant growth promoters. China GB 2760-86 provides the product can be used as a spice. 2 as amino acid infusion and comprehensive amino acid formulations. For the diagnosis and treatment of early childhood idiopathic hyperglycemia. And applies to sugar metabolism disorders, associated with reduced secretion of bile, liver disease, anemia, poisoning, muscular atrophy, poliomyelitis, neuritis, and mental illness. |
| CAS Registry Number: | CAS: 61-90-5 |
| Company: | Wuhan Yuancheng Gongchuang Technology Co., Ltd. [ China ] |
| Contact: | shelly huang |
| Tel: | 86-27-88064757 |
| Fax: | 86-27-88048077-833 |
| Email: | zc07@yccreate.com |
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