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Progesterone Hormones Chlormadinone acetate (CAS No. 302-22-7 ) CMA
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| Post Date: | Oct 23,2015 |
| Expiry Date: | Oct 22,2016 |
| Detailed Description: |
Cas No. :302-22-7
Quantity: 10Kilograms Specs:KOSHER,GMP,SGS,ISO9001 Price:1 USD Kilograms Payment Method: Western Union,Moneygram,Banktransfer,T/T Progesterone Hormones Chlormadinone acetate (CAS No. 302-22-7 ) CMA Quick details: Chlormadinone acetate Product name: Chlormadinone acetate CAS Registry Number: 302-22-7 Assay: 98% Molecular Formula: C23H29ClO4 Molecular weight: 404.93 Reference Standard: CP Appearance: White or slightly yellow crystalline powder Also known as: Gestafortin, Menstridyl, Matrol, Cero, Chlormadinon acetate, Bovisynchron, Fertiletten, Chlordion, Clordion Molecular Formula: C23H29ClO4 Molecular Weight: 404.92696 InChIKey: QMBJSIBWORFWQT-DFXBJWIESA-N An orally active synthetic progestational hormone used often in combinations as an oral contraceptive. Description: Chlormadinone acetate (INN, USAN, BAN, JAN; sold under brand names including Clordion, Gestafortin, Lormin, Non-Ovlon,Normenon, Verton, and many others) (CMA) is a derivative of progesterone (17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect - about one-third higher than that of progesterone - and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans. The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors - competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone - and the competitive inhibition of 5α-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect. |
| CAS Registry Number: | 302-22-7 |
| Synonyms: | ;17-Acetoxy-6-Chloro-6-Dehydroprogesterone;6-Chloro-3,20-Dioxopregna-4,6-Dien-17-Yl Acetate;(8Xi,9Xi,14Xi)-6-Chloro-3,20-Dioxopregna-4,6-Dien-17-Yl Acetate; |
| Molecular Formula: | C23H29ClO4 |
| Molecular Weight: | 404.927 |
| Molecular Structure: | 
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| Hazard Symbols: |  T:Toxic; |
| Risk Codes: | R60:; R61:; R40:; R48:; |
| Safety Description: | S53:; S22:; S36/37/39:; S45:; |
| Company: | Hongkong Yuancheng Gongchuang Technology Co.Ltd. [ China ] |
| Contact: | sunny |
| Tel: | 86-027-50756220 |
| Fax: | |
| Email: | sunny@ycphar.com |
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