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Selumetinib

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  Post Date: Mar 24,2015
  Expiry Date: Apr 23,2015
  Detailed Description: Cas No. :606143-52-6 Quantity: 5mgFCL
Price:30 USD FCL
Payment Method: T/T, Western Union
Introduction: Selumetinib, activating mutations in the BRAF gene, primarily at V600E, are associated with poorer outcomes in patients with papillary thyroid cancer.[clarification needed] MAPK kinase (MEK), immediately downstream of BRAF, is a promising target for MAPK/ERK pathway inhibition. In addition to thyroid cancer, BRAF-activating mutations are prevalent in melanoma (–59%), colorectal cancer (5–22%), serous ovarian cancer (–30%), and several other tumor types. Four lines bearing V600E BRAF mutations were all sensitive to selumetinib, with GI50 values ranging from 14 to 50 nM. A positive control BRAF mutant melanoma line, SKMel28, exhibited a similar GI50 of 23 nM. A Phase II clinical trial about selumetinib in cancers with BRAF mutations is ongoing.

CAS Number: 606143-52-6
Name: 1H-benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
Superlist Name: AZD 6244
Formula: C17H15BrClFN4O3
Molecular Weight: 457.68
Synonyms: AZD 6244;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;
Density: 1.692 g/cm3

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  CAS Registry Number:

606143-52-6
  Synonyms: ;ZD-6244;ARRY-142886;AZD6244;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;AZD 6244;AZD-6224;5-(4-Bromo-2-chlorophenylamino)-4-fluoro-1-methyl-1H-benzimidazole-6-carbohydroxamic acid 2-hydroxyethyl ester;
  Molecular Formula: C17H15BrClFN4O3
  Molecular Weight: 457.6813
  Molecular Structure: 606143-52-6 Selumetinib

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