Home > Offer to Sell > Pharmaceuticals and Biochemicals > Antibiotic and antimicrobial agents > Sindose
Sindose
Inquiry
| Post Date: | Aug 12,2014 |
| Expiry Date: | Aug 12,2015 |
| Detailed Description: |
Cas No. :3366-95-8
Quantity: 10Kilograms Specs:Sindose,Secnidazole,3366-95-8 Price:1-10000 USD Kilograms Payment Method: T/T,L/C.WU Product Name： Secnidazole Other names: Flagentyl, Sindose, Secnil Category: pharmaceutical raw material bulk drugs api CAS NO: 3366-95-8 M.F.: C7H11N3O3.1/2H20 Quality standard: YBH12562008; Edition: CP Applicable category:Antianaerobic-microbacterial drug,antitrichomonal agent ; Finished dosage: Secnidazole capsules, Secnidazole tablets ; Appearance: almost white to pale yellow crystalline powder,odourless,bitter flavor; Freely soluble in ethanol, chloroform and propanol,sparingly soluble in 0.1mol/l hydrochloric acid, slightly soluble in water; Assay: not less than 99% on anhydrous basis; Loss on drying: 4.5 %~6% Appearance of solution: clear and colorless; Melting point: 74~78℃; Related impurities:The peak area of total impurities ≤1%; Heavy metal: ≤10 ppm; Packing: 10 kg/drum Advantage: High purity, Low heavy metal, Low related impurities, GMP certificate, Profession Activity & Sevice: pharmaceuticals looking for distributors, wholesale pharmaceutical generic drugs, provide lab testing service pharmaceutical Product Introduction: Secnidazole is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported.It has also been tested against Atopobium vaginae. Secnidazole is structurally related to the commonly used 5-nitroimidazoles metronidazole and tinidazole. These drugs share a common spectrum of activity against anaerobic micro-organisms and they appear particularly effective in the treatment of amoebiasis, giardiasis, trichomoniasis and bacterial vaginosis. Secnidazole is rapidly and completely absorbed after oral administration and has a longer terminal elimination half-life (approximately 17 to 29 hours) than commonly used drugs in this class. In patients with intestinal amoebiasis or giardiasis, clinical or parasistological cure rates of 80 to 100% are achieved after treatment with a single dose of secnidazole 2 g (30 mg/kg in children), similar to the response rates achieved with multiple dosage regimens of metronidazole or tinidazole. Patients with hepatic amoebiasis appears to respond well to 5- to 7-day therapy with secnidazole, but the efficacy of this drug regimen requires further evaluation in larger numbers of patients. After administration of a single dose of secnidazole, parasitological eradication was achieved in approximately 92 to 100% of patients with urogenital trichomoniasis. Patients with bacteria vaginosis respond at least as well to a single dose of secnidazole as to single-dose tinidazole, or single- or 7-day treatment with metronidazole; clinical improvement and/or microbiological evidence of cure was attained in approximately 59 to 96% of patients. In the clinical trials reviewed, secnidazole was well tolerated; most adverse events were gastrointestinal in nature and did not require treatment intervention or withdrawal from therapy. In summary, available evidence suggests that secnidazole is as efficacious as other 5-nitroimidazole drugs in the treatment of protozoal infections and bacterial vaginosis. The convenience and ease of administration associated with single-dose therapy, combined with a good tolerability profile, make secnidazole a suitable option to other single-dose treatments and an attractive alternative to multiple dosage regimens with other drugs in this class. |
| CAS Registry Number: | 3366-95-8 |
| Synonyms: | ;alpha,2-dimethyl-5-nitro-1h-imidazole-1-ethanol;1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol; |
| Molecular Formula: | C7H11N3O3 |
| Molecular Weight: | 185.1805 |
| Molecular Structure: | 
|
| Company: | Hunan Dinuo Pharmaceuical Co.,Ltd [ China ] |
| Contact: | Cuckoo Deng,Jennifer Wang |
| Tel: | +86-0731-88280100-8561/2 |
| Fax: | +86-0731-88280157 |
| Email: | sales@cphi-dinuo.com |
-
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.
