Spironolactone
Inquiry
| Post Date: | Sep 30,2019 |
| Expiry Date: | Mar 28,2020 |
| Detailed Description: | Cas No. :52-01-7 Spironolactone is a diuretic for the treatment of edematous diseases and primary aldosteronism, as an adjunct to the treatment of hypertension and prevention of hypokalemia. The drug is similar in structure to aldosterone and is a competitive inhibitor of aldosterone. Acting on the distal convoluted tubule and collecting tube, blocking Na+-K+ and Na+-H+ exchange, the results showed that Na+, C1- and water excretion increased, K+, Mg2+ and H+ excretion decreased, and the effects on Ca2+ and P3- were uncertain. Because the drug only acts on the distal convoluted tubules and collecting ducts, it has no effect on other segments of the renal tubules, so the diuretic effect is weak. In addition, the drug also has an effect on aldosterone target organs other than the renal tubules. |
| CAS Registry Number: | 52-01-7 |
| Synonyms: | ;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta- carbolactone; ;S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate;S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate;S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate;17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate; |
| Molecular Formula: | C24H32O4S |
| Molecular Weight: | 416.5735 |
| Molecular Structure: | 
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| Hazard Symbols: |  T:Toxic; Xn:Harmful; |
| Risk Codes: | R40:; R60:; |
| Safety Description: | S53:; S22:; S36/37/39:; S45:; |
| Company: | Wuhan Eighteen International Trade Co., LTD [ China ] |
| Contact: | Dina |
| Tel: | 15919805491 |
| Fax: | |
| Email: | eighteeninfo009@163.com |
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