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Tetrodotoxin TTX (citrate free)

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  Post Date: Mar 18,2013
  Expiry Date: Mar 18,2014
  Detailed Description: Cas No. :4368-28-9 Quantity: 1mg
Specs:>98%
Price:115 USD Metric Tons
Tetrodotoxin (citrate free) is a Selective inhibitor of Na ++ channel conductance. Binding is reversible and of high affinity (Kd = 1-10 nM).Blocks in a use-dependent manner.
References :
1.Kao (1972) Pharmacology of tetrodotoxin and saxitoxin. Fed.Proc. 31 1117. PMID: 5032475.
2.Catterall WA Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu Rev Pharmacol Toxicol 20:15-43 (1980). Read more (PubMed: 6247957)
3.Kao (1986) Structure-activity relations of tetrodotoxin, saxitoxin, and analogues. Ann.N.Y.Acad.Sci. 479 52. PMID: 2434008.
4.Narahashi T et al. Recent advances in the study of mechanism of action of marine neurotoxins. Neurotoxicology 15:545-54 (1994). Read more (PubMed: 7854588)
5.Gleitz et al (1996) The protective action of tetrodotoxin and (±)-kavain on anaerobic glycolysis, ATP content and intracellular Na+ and Ca2+ of anoxic brain vesicles. Neuropharmacology 35 1743. PMID: 9076753.
6.Hille, B. (2001) Ion Channels in Excitable Membranes (Third Edition) Chapter 3

  CAS Registry Number:

4368-28-9
  Synonyms: ;(1R,5S,6R,7S,9S,11S,12S,13S,14S)-3-amino-5,9,12,13,14-pentahydroxy-14-(hydroxymethyl)-8,10-dioxa-2-aza-4-azoniatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene (non-preferred name);(1R,5S,6R,7S,9S,11S,12S,13S,14R)-3-amino-5,9,12,13,14-pentahydroxy-14-(hydroxymethyl)-8,10-dioxa-2-aza-4-azoniatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene (non-preferred name);(1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.17,11.01,6]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name);
  Molecular Formula: C11H17N3O8
  Molecular Weight: 319.268
  Molecular Structure: 4368-28-9 Tetrodotoxin

  Company: AffixScientific     [ United States ]        
  Contact: Rob Martin
  Tel: +1-510-936-6647
  Fax: +1-510-936-6647
  Email: rob@affixscientific.com
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