Tibolone
Inquiry
| Post Date: | Sep 10,2017 |
| Expiry Date: | Mar 09,2018 |
| Detailed Description: |
Cas No. :5630-53-5
Payment Method: T/T, Western Union, MoneyGram Basic Info. Product name: Tibolone Alias: LIVIELLA; LIVIAL CAS: 5630-53-5 EINECS: 227-069-1 Assay: 99% min. MF: C21H28O2 MW: 312.45 Appearance: White or off-white crystal powder Grade: Pharmaceutical Grade Storage: Shading, confined preservation Usage: It is a synthetic hormone-type drug which is used mainly for hormone replacement therapy in post-menopausal women. Product Description: Tibolone (Livial/Liviella) is used mainly for treatment of endometriosis, as well as hormone replacement therapy in post-menopausal women. Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist mainly at estrogen receptors, with a preference for ER alpha. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile. It has also been investigated as a possible treatment for female sexual dysfunction. Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist mainly at estrogen receptors, with a preference for ER alpha. It is used mainly for treatment of endometriosis,as well as hormone replacement therapy in post-menopausal women. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile.It has also been investigated as a possible treatment for female sexual dysfunction. Applications: Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women. |
| CAS Registry Number: | 5630-53-5 |
| Synonyms: | ;-TIBOLONE;LIVIELLA;LIVIAL;5(10)-ESTREN-7-ALPHA-METHYL-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE;(7A,17A)-17-HYDROXY-7-METHYL-19-NORPREGN-5(10)-EN-20-YL-3-ONE;17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one;17ALPHA-HYDROXY-7ALPHA-METHYL-19-NORPREGN-5(10)-EN-20-YN-3-ONE;19-NORPREGN-5(10)-EN-20-YN-3-ONE,17-HYDROXY-7-METHYL-, (7A,17A)-;(7alpha,8xi,13xi,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)-en-3-one;(7alpha,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)-en-3-one; |
| Molecular Formula: | C21H28O2 |
| Molecular Weight: | 312.4458 |
| Molecular Structure: | 
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| Hazard Symbols: |  N:; |
| Risk Codes: | 51/53:; |
| Safety Description: | 22-24/25-61:; |
| Company: | Guangzhou Kafen Biotech Co.,Ltd [ China ] |
| Contact: | laura Lin |
| Tel: | +8613332873040 |
| Fax: | |
| Email: | laura@rawroid.com |
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