Topiramate(CAS No. 97240-79-4)
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| Post Date: | Sep 02,2013 |
| Expiry Date: | Sep 09,2013 |
| Detailed Description: |
Name:Topiramate CAS Registry number:97240-79-4 Synonyms:McN-4853;Epitomax; 2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranos sulfamate; a-D-Fructopyranose,2,3:4,5-bis-O-(1-methylethylidene)-,sulfamate; Tipiramato [Spanish];Topamax; Topiramate [USAN:BAN:INN] more details can be found on the page:http://www.guidechem.com/reference/dic-28727.html. Usage:Used as an anticonvulsant Biomedical Effects and Toxicity Biological Activity: Anticonvulsant. Antagonizes GluR5 kainate receptors (IC 50 = 0.46 μ M), acts as a positive allosteric modulator of GABA A receptor-mediated currents, inhibits Na v channels (IC 50 = 48.9 μ M) and inhibits L-type Ca 2+ channels. Also inhibits carbonic anhydrase (CA) (K i values are 0.1 and 0.2 μ M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH. |
| Company: | run-biotech Co., Ltd. [ China ] |
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