Trilostane
Inquiry
| Post Date: | Sep 10,2017 |
| Expiry Date: | Mar 09,2018 |
| Detailed Description: |
Cas No. :13647-35-3
Payment Method: T/T, Western Union, MoneyGram Basic Info. Trilostane Synonym: Vetoryl CAS : 13647-35-3 Molecular Formula: C20H27NO3 Molecular Weight: 329.4333 Assay :99% Einecs No: 237-133-0 Grade : Pharmaceutical Grade Storage: Shading, confined preservation Appearance:: White crystalline powder Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level. Product Description: Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland. Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids. Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting. Application: Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase disease) and primary aldosteronism,the effect is not good than testosterone metyrapone. This product has significantly reduced blood testosterone level role, may relevant to its inhibit synthetic. |
| CAS Registry Number: | 13647-35-3 |
| Synonyms: | ;17-hydroxy-3-oxo-4,5-epoxyandrostane-2-carbonitrile;(4alpha,5alpha,17beta)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile; |
| Molecular Formula: | C20H27NO3 |
| Molecular Weight: | 329.4333 |
| Molecular Structure: | 
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| Company: | Guangzhou Kafen Biotech Co.,Ltd [ China ] |
| Contact: | laura Lin |
| Tel: | +8613332873040 |
| Fax: | |
| Email: | laura@rawroid.com |
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