Triptorelin 57773-63-4
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| Post Date: | Aug 19,2015 |
| Expiry Date: | Feb 15,2016 |
| Detailed Description: |
Cas No. :57773-63-4
Triptorelin
email:jaymee at ycphar dot com. Triptorelin Acetate CAS No.: 57773-63-4 Sequence: GLP-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-PRO-Gly-NH2 Purity (HPLC): 98.0% min. Appearance: White powder Molecular Formula: C64H82N18O13 Molecular Weight: 1311.46 Single Impurity (HPLC): 1.0%max Amino Acid Composition: ± 10% of theoretical Peptide Content (N%): ≥ 80.0% Water Content(Karl Fischer): ≤ 6.0% Acetate Content (HPIC): ≤ 15.0% MS(ESI): Consistent Mass Balance: 95.0~105.0% Specific Rotation (20/D): -65.0~-75.0° (c=0.5 1%HAc) Triptorelin Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl . In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl (Varian Darou Pajooh). In India, Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA". During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy. Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. |
| CAS Registry Number: | 57773-63-4 |
| Synonyms: | ;[D-Trp6]-LH-RH; |
| Molecular Formula: | C66H88N18O15 |
| Molecular Weight: | 1373.5165 |
| Molecular Structure: | 
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| Company: | Yuanchength [ China ] |
| Contact: | Jaymee |
| Tel: | +86-27-50756221 |
| Fax: | |
| Email: | jaymee@ycphar.com |
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