Unii-U2Y5ofn795 CAS: 649735-63-7
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| Post Date: | Sep 23,2016 |
| Expiry Date: | Mar 22,2017 |
| Detailed Description: |
Cas No. :649735-63-7
Quantity: 0.01Kilograms Price:1.25 USD Kilograms Unii-U2Y5ofn795 CAS: 649735-63-7 Product Name BMS582664 Molecular Formula C22H24FN5O4 Molecular Weight 369.3696232 Storage Store at -20°C Targets VEGFR2 Flk1 FGFR1 VEGFR1 IC50 25 nM 89 nM 148 nM 380 nM Dosage 90 mg/kg E:steroidcn at ycgmp.com Sky:live:bella881030 Details: Synonyms:Bms 582664;Bms582664;Brivanib alaninate;L-Alanine, (1R)-2-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-1-methylethyl ester;Unii-U2Y5ofn795;(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester;Brivanib alaninate(BMS-582664);L-Alanine (1R)-2-[[4-[(4-fluoro-2-Methyl-1H-indol-5-yloxy)]-5-Methyl-1H-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]isopropyl ester Description:Brivanib Alaninate (BMS-582664) BMS-540215 is a prodrug, an ATP competitive VEGFR2 inhibitor, IC50 of 25 nM. Application: BMS-582664 inhibits VEGF and FGF-stimulated HUVECs proliferation, IC50 of 40 nM, respectively, and 276 nM. [1] BMS-582664 (2 μM) acting on the VEGF and bFGF stimulated SK-HEP1 cells and HepG-2 cells, significantly inhibited VEGFR-2, FGFR-1, ERK1 / 2 and Akt phosphorylation, and BMS-582664 alone in unstimulated cells, then the ERK1 / 2, Akt, VEGFR-2, and the level of phosphorylation of FGFR-1 has no effect. [2] BMS-582664 to inhibit CYP2C19, CYP3A4 (BFC) and CYP3A4 (BzRes), IC50 were 2.4 μM, 0.51 μM and 1.6 μM. BMS-582664 has a high solid state stability (only 0.3% in the desiccant during 12 weeks at 50 ° C degradation), while at pH 6.5 also has considerable liquid stability. [3] |
| CAS Registry Number: | 649735-63-7 |
| Synonyms: | BMS582664;Brivanib alaninate;(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester; |
| Molecular Formula: | C22H24FN5O4 |
| Molecular Weight: | 441.4555 |
| Molecular Structure: | ![649735-63-7 L-Alanine,(1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethylester](https://images.chemnet.com/suppliers/chembase/cas216/649735-63-7.jpg)
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| Company: | Gongchuang Technology Co.,Ltd [ China ] |
| Contact: | Bella Lee |
| Tel: | 86-27-50755950 |
| Fax: | |
| Email: | steroidcn@ycgmp.com |
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