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Zinc bacitracin(toni@ycgmp.com)
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| Post Date: | Jun 25,2015 |
| Expiry Date: | Jun 24,2016 |
| Detailed Description: |
Payment Method: t/t Zinc bacitracin CAS: 1405-89-6 Zinc bacitracin MF: C66H101N17O16SZn Zinc bacitracin MW: 1486.06994628906 Zinc bacitracin EINECS: 215-787-8 Zinc bacitracin mp 250 °C (dec.) Zinc bacitracin storage temp. 2-8°C Zinc bacitracin solubility 10 mM HCl: 5 mg/mL, clear, faintly yellow-green Zinc bacitracin Water Solubility 5.1 g/L (28 ºC) Zinc bacitracin Properties White to pale buff powder Zinc bacitracin Categories: API intermediates; Steroids; Veterinaries Zinc bacitracin Usage Bacitracin zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM. Uses This medication is used to prevent minor skin infections caused by small cuts, scrapes, or burns. Bacitracin works by stopping the growth of certain bacteria. It belongs to a class of drugs known as antibiotics. This antibiotic only prevents bacterial infections. It will not work for virus or fungus infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness. Do not use this product over large areas of the body. Do not use it for serious skin infections. Ask your doctor first before using this product for serious skin injuries (such as deep or puncture wounds, animal bites, serious burns). A different treatment may be necessary for these types of conditions. Consult your doctor for more information. Zinc bacitracin is a mixture of high molecular weight polypeptides (bacitracin A, B and C and several minor components), first described in 1945 as a product of a Bacillus sp. (now recognized as Bacillus licheniformis), contaminating wounds. It has activity against some Gram-positive organisms, among which Staphylococcus aureus is somewhat less susceptible and Streptococcus pyogenes is highly susceptible. It is noteworthy that the high susceptibility of S. pyogenes, established by Maxted in 1953, still obtains and continues to be used as a diagnostic test for Lancefield Group A streptococci.1 Bacitracin acts bactericidally by binding to isoprenyl pyrophosphate, the lipid carrier that transfers N-acetylmuramyl-N-acetylglucosamyl-amino acid cell wall building blocks across the cytoplasmic membrane, a mechanism unlike that of any other commercially available antibiotic. Acquired resistance is known, for example in S. aureus, but is uncommon. Other organisms, such as enterococci, seem always to have varied in their susceptibility. There is no cross-resistance with other antibiotics. Upon introduction into clinical use in man, bacitracin was found to be nephrotoxic, and preparations for systemic use were soon withdrawn. However, it continued to be used topically, and is still used for the treatment of infected dermatoses and other skin infections, for infected wounds and the prevention of infection in dirty wounds, although to a diminished extent now other more effective agents have taken its place. The products containing bacitracin are ointments (including ophthalmic preparations) and various antibiotic sprays, in which it is mixed with such antibiotics as polymyxin and neomycin. The antibiotic sprays have rarely been favoured by microbiologists since they have been associated with both bacitracin and neomycin resistance, even though only the latter is of great clinical importance. The current lack of importance of bacitracin in human medicine is demonstrated by the fact that very little space is given to it in specialized (let alone general) textbooks. The seventh Edition of Antibiotic and Chemotherapy by O'Grady et al.,1 the major British textbook on antibiotics, gives it only half a page or so among its 1000 pages, while Lorian's compendious textbook Antibiotics in Laboratory Medicine2 mentions it virtually only in passing, with MIC information only on Neisseria meningitidis-one line in about 150 pages of tabulated susceptibility data. In contrast to its low level of use in humans, bacitracin has had an important role as a growth promoter in animal husbandry. Here, in addition to being effective in its primary role, it appears to have the additional advantage of suppressing necrotizing enteritis owing to Clostridium perfringens. Brands: Baciguent, Baci-Rx, Bactine First Aid Antibiotic Plus Anesthetic, Band-Aid with Antibiotic, Betadine Brand First Aid Antibiotics + Moisturizer, Betadine Brand First Aid Antibiotics + Pain Reliever, Campho-Phenique First Aid Antibiotic Plus Pain Reliever Maximum Strength, Double Antibiotic, Mycitracin Plus Pain Reliever, Neosporin, Neosporin Plus Maximum Strength First Aid Antibiotic/Pain Relieving, Polysporin, Spectrocin Plus, Triple Antibiotic, Triple Antibiotic Extra, Zeba-Rx |
| Company: | Hulumimi Pharmaceuticals [ China ] |
| Contact: | Toni Zhong |
| Tel: | 027-50756080 |
| Fax: | 0086-27-88048077-794 |
| Email: | toni@ycgmp.com |
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