(+)-Griseofulvin

• Post Date:

  Sep 10,2014

• Expiry Date:

  Mar 09,2015

• Detailed Description:

  Cas No. :126-07-8 Quantity: 25Kilograms
  Name (+)-Griseofulvin
  Synonyms (2S)-trans-7-Chloro-2',4,6-trimethoxy-6'-methylspiro(benzofuran-2[3H],1'-[2]cyclohexene)-3,4'-dione
  Product Name: (+)-Griseofulvin
  Synonyms: (+)-GRISEOFULVIN;GRISEOFULVIN;[2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6'-METHYLSPIRO[BENZOFURAN-2(3H), 1'(2)-CYCLOHEXANE]-3,4'-DIONE;(2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-[2]CYCLOHEXENE)-3,4'-DIONE;7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYL-, (1'S-TRANS)-SPIRO(BENZOFURAN-2(3H),1'-(2)CYCLOHEXENE)-3,4'-DIONE;(+)-griseofulvi;(2s-trans)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3h),1’-[2]cy;(2s-trans)-xy-6’-methyl
  CAS: 126-07-8
  MF: C17H17ClO6
  MW: 352.77
  EINECS: 204-767-4
  Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Antifungal;Aromatics;Chiral Reagents;VERELAN
  Mol File: 126-07-8.mol
  (+)-Griseofulvin Chemical Properties
  mp 218-220 °C(lit.)
  alpha 354 º (c=1, dimethylform)
  storage temp. −20°C
  Water Solubility practically insoluble
  Merck 14,4549
  BRN 95226
  CAS DataBase Reference 126-07-8(CAS DataBase Reference)
  NIST Chemistry Reference Griseofulvin(126-07-8)
  EPA Substance Registry System Spiro[benzofuran- 2(3H),1'-[2]cyclohexene]- 3,4'-dione, 7-chloro-2',4,6-trimethoxy- 6'-methyl-, (1'S,6'R)-(126-07-8)
  Safety Information
  Hazard Codes T,Xn
  Risk Statements 60-61-40-43-45
  Safety Statements 53-22-36/37/39-45
  WGK Germany 3
  RTECS WG9800000
  Hazardous Substances Data 126-07-8(Hazardous Substances Data)
  MSDS Information
  Provider Language
  (+)-Griseofulvin English
  SigmaAldrich English
  ACROS English
  ALFA English
  (+)-Griseofulvin Usage And Synthesis
  Chemical Properties Crystalline Solid
  Usage adrenegic blocker, Ca channel blocker, coronary vasodilator, antiarrhythmic
  Usage antifungal, inhibits mitosis in metaphase
  Usage Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin's ability to bind to keratin is considered an important aspect of the metabolite's access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy.
  Usage It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum
  General Description White to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. Sublimes without decomposition at 410°F.
  Air & Water Reactions Insoluble in water.
  Reactivity Profile (+)-Griseofulvin is incompatible with strong oxidizing agents. .
  Fire Hazard Flash point data for (+)-Griseofulvin are not available. (+)-Griseofulvin is probably combustible.
  (+)-Griseofulvin Preparation Products And Raw materials
  Raw materials Starch-->Oxalic acid

• CAS Registry Number:

  126-07-8

• Synonyms:

  ;grisovin;7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2R,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2S,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohexane]-3,4'-dione;Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione,7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'R-trans)-;(+)-Griseofulvin;

• Molecular Formula:

  C₁₇H₁₉ClO₆

• Molecular Weight:

  354.7822

• Molecular Structure:

  

• Hazard Symbols:

   T:Toxic;
  

• Risk Codes:

  R60:;
  R61:;
  R40:;
  R43:;
  

• Safety Description:

  S53:;
  S22:;
  S36/37/39:;
  S45:;
  

• Company:

  Hubei MaxSource Chem Co., Ltd.     [ China ]        

• Contact:

  jackie xiao

• Tel:

  +86-27-83555670

• Fax:

• Email:

  maxsource14@hotmail.com