10-Deacetyl-7-xylosyl paclitaxel cas90332-63-1

• Post Date:

  Jan 11,2016

• Expiry Date:

  Jan 10,2017

• Detailed Description:

  Cas No. :90332-63-1 Quantity: 1Kilograms
  Specs:98%
  Price:1 USD Metric Tons
  Payment Method: T/T
  Availability: In Stock
  Cat No.: 90332-63-1
  Biological Description:
  10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility.
  IC50 value:
  Target: Microtubule inhibitor
  10-Deacetyl-7-xylosyl paclitaxel induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9. In turn, caspase-9 activated downstream caspases-3 and -6, but not caspase-8. Bid was also activated by caspase-3. Reversely, treatment with a caspase-10-specific inhibitor could not protect PC-3 cells from 7-xylosyl-10-deacetyl-paclitaxel-triggered apoptosis. Moreover, 7-xylosyl-10-deacetylpaclitaxel had no effect on the expression of CD95 and NF-kappaB proteins, indicating that apoptosis was induced through the mitochondrial-dependent pathway i...
  
  Purity: >98%
  
  Molecular formula: C50H57NO17
  
  Molecular Weight: 943.98
  
  Storage Instructions: Two years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

• CAS Registry Number:

  90332-63-1

• Synonyms:

  10-Deacetyltaxol 7-xyloside; b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester

• Molecular Formula:

  C₅₀H₅₇NO₁₇

• Molecular Weight:

  943.98

• Molecular Structure:

  

• Company:

  SHENZHEN NEXCONN PHARMATECHS LTD.     [ China ]        

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