AZD1152-HQPA

Post Date:
Apr 03,2015
Expiry Date:
Apr 02,2016
Detailed Description:
Cas No. :722544-51-6 Quantity: 50g
Specs:98% purity
Payment Method: T/T, Western Union
AZD-1152 is a novel acetanilide-substituted pyrazole-aminoquinazoline prodrug that is converted rapidly to the active drug AZD-1152 hydroxy-QPA (AZD1152-HQPA) in human plasma. AZD1152-HQPA is a specific inhibitor of the enzymatic activity of Aurora kinase, with selectivity for Aurora B (IC50 of 0.37 nM versus 1368 nM for Aurora B and A kinases, respectively); the inhibitor had even less activity against a panel of greater than 50 other serine-threonine and tyrosine kinases including FLT3, JAK2, and Abl. Preliminary studies showed that AZD-1152 was active against a variety of solid tumors including colon, breast,and lung cancers.
CAS Registry Number:
722544-51-6

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