Abiraterone acetate

• Post Date:

  Jun 06,2020

• Expiry Date:

  Jun 06,2021

• Detailed Description:

  Cas No. :154229-18-2 Quantity: 1Metric Tons
  Specs:99%min
  Product Name: Abiraterone acetate
  Synonyms: (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate;[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;(3β)-17-(3-pyridinyl) androsta-5,16-dien-3-yl acetate;Abiraterone acetate, >=99%;Abirteroneacetate;ZYTIGA;Abiraterone acetate - CB 7630 | JNJ 212082;Abiraterone Acotate
  CAS: 154229-18-2
  MF: C26H33NO2
  MW: 391.55
  EINECS: 620-314-7
  Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;API;DQM;Inhibitor;Final material;Anti-cancer & immunity
  Mol File: 154229-18-2.mol
  Abiraterone acetate Structure
  Abiraterone acetate Chemical Properties
  Melting point 127-130°C
  Boiling point 506.7±50.0 °C(Predicted)
  density 1.14±0.1 g/cm3(Predicted)
  storage temp. -20°C Freezer
  pka 5.31±0.12(Predicted)
  form powder
  color white to beige
  Safety Information
  WGK Germany 3
  RTECS BV7992100
  HS Code 2937290000
  MSDS Information
  Abiraterone acetate Usage And Synthesis
  Description In April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).
  Chemical Properties Off-White Solid
  Originator Institute of Cancer Research, London (United Kingdom)
  Uses A novel steroidal inhibitor of human Cytochrome P450(17a-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
  Uses Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
  Uses A steroidal inhibitor of CYP17A1 in androgen biosynthesis
  Definition ChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance .
  Brand name Zytiga

• CAS Registry Number:

  154229-18-2

• Synonyms:

  ;(3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester);Abiraterone Acetate;CB 7630;(3beta,8xi,9xi,14xi)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate;

• Molecular Formula:

  C₂₆H₃₃NO₂

• Molecular Weight:

  391.5457

• Molecular Structure:

  

• Company:

  shanghai missyou chemical co.,ltd.         

• Contact:

  eileen zhang

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  021-58583907

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