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Acitretin CAS 55079-83-9

  • Post Date:

    Dec 23,2024
  • Expiry Date:

    Dec 23,2025
  • Detailed Description:

    Cas No. :55079-83-9 Payment Method: LC/TT
    Acitretin
    Product Name: Acitretin
    SPEC:EP6.0
    CAS No.:55079-83-9
    MFC21H26O3
    Melting Point: 228-230°C
    Packing: 25kg/drum
    Appearance: Yellow crystalline powder

    Storage: Sealed tightly and stored away from light in a cool and dry place.
    Place of origin: China.
    Validity: 2 years
    Packing: 1kg/foil bag, or 25kg/carton drum


    Product Description:

    Acitretin (trade names Soriatane and Neotigason) is a second-generation retinoid. It is taken orally, and is typically used forpsoriasis.
    It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life(t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.
    Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocytedifferentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer.
    Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.


    Applications:

    Acitretin (CAS NO.55079-83-9) is a synthetic retinoid which is the major metabolite of etretinate. It is typically used for psoriasis. Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin.



    Specification

    Test Items Standard Result
    Description A yellow or greenish-yellow crystalline powder conform
    Identification Shall comply All comply
    Loss on dressing ≤0.5% 0.32%
    Sulphated ash ≤0.1 0.09%
    Heavy metals ≤20ppm conform
    Related substance
    Individual impurities ≤0.3 0.21%
    Total impurities ≤1.0% 0.40%
    Assay(on dried basis) 98.0%-102.0% 99.5%
    Conclusion The results conform with EP6.0

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  • CAS Registry Number:

    55079-83-9
  • Synonyms:

    ;9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid;Neotigason;Soriatane;acitretin;(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid;(2Z,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid;
  • Molecular Formula:

    C21H26O3
  • Molecular Weight:

    326.4293
  • Molecular Structure:

    55079-83-9 Etretin
  • Hazard Symbols:

     T:Toxic;
     N:Dangerous for the environment;
  • Risk Codes:

    R36/38:;
    R61:;
    R50/53:;
  • Safety Description:

    S53:;
    S37/39:;
    S45:;
    S60:;
    S61:;
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