Acotiamide

Post Date:
Dec 07,2018
Expiry Date:
Dec 07,2019
Detailed Description:
Cas No. :185106-16-5

Pharmacokinetic data

Protein binding
84.21–85.95%

Metabolism
UGT1A8 and 1A9 (major)

Biological half-life
10.9–21.7 hours

Excretion
Feces (92.7%), urine (5.3%)[1]

Identifiers

IUPAC name[show]

N-{2-[bis(1-Methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide

CAS Number

185106-16-5 N

PubChem CID

5282338

ChemSpider

4445505 Y

UNII

D42OWK5383

KEGG

D08838 N

ChEMBL

CHEMBL2107723 N

Chemical and physical data

Formula
C21H30N4O5S

Molar mass
450.55 g/mol

3D model (Jmol)

Interactive image

SMILES[show]

O=C(Nc1nc(C(=O)NCCN(C(C)C)C(C)C)cs1)c2cc(OC)c(OC)cc2O

InChI[show]

InChI=1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27) Y

Key:TWHZNAUBXFZMCA-UHFFFAOYSA-N Y

NY (what is this?) (verify)

Acotiamide (brand name Acofide, codenamed YM-443 and Z-338) is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.[2] It acts as an acetylcholinesterase inhibitor.
CAS Registry Number:
185106-16-5
Synonyms:
;N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide;Acotiamide;
Molecular Formula:
C₂₁H₃₀N₄O₅S
Molecular Weight:
450.5517
Molecular Structure:

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