Albendazole CAS NO. :54965-21-8

• Post Date:

  Mar 30,2013

• Expiry Date:

  Mar 30,2014

• Detailed Description:

  Cas No. :54965-21-8 Quantity: 20Metric Tons
  Payment Method: TT/LC/DP
  Albendazole CAS NO. :54965-21-8
  
  ALIAS:Methyl5-propylthio-2-benzimidazolecarbamate
  CAS NO. :54965-21-8
  Formula:C12H15N3O2S
  Molecular Weight:265.33
  
  Effects and purposes
  This product is metabolized in the body to the sulfoxide or sulfone parasites, inhibit the absorption of glucose, resulting in parasite glycogen depletion, or inhibition of fumarate reductase system, hinder ATP production, the parasite can not survive and reproduce. This product is a high efficiency and low toxicity, broad-spectrum anthelmintic. Clinical can be used to drive the roundworm, pinworm, tapeworm, whipworm, hookworm, fecal round nematodes.
  
  [Properties] white or off-white powder, odorless, tasteless, insoluble in water, slightly soluble in acetone or chloroform.
  
  [Category] anti-infective medicines >> >> anti-parasitic disease medicine against intestinal worm disease drug
  
  Pharmacological
  
  The benzimidazole derivatives of the strains, and its rapid metabolism in the body for a sulfoxide, a sulfone alcohol and 2 - amine sulfone alcohol. Intestinal nematode selectively and reversibly inhibit the the parasite intestinal wall system of cytoplasmic microtubules polymerization, block the uptake of a variety of nutrition and glucose absorption, cause insects endogenous glycogen depletion and inhibition of fumaric acid reduction enzyme system, to prevent the generation of adenosine triphosphate, causing parasite can not survive and reproduce. Mebendazole similar, the product can also cause parasite intestinal cytoplasmic microtubules degeneration and its tubulin binding, resulting in intracellular transport to clogging, resulting in the accumulation of Golgi endocrine granules, cytoplasm gradually dissolve, absorb the complete denaturation of the cells, death caused by parasites. This product has completely killed the hook eggs and whip the eggs and partially kill Ascaris eggs. Addition can kill to get rid of all kinds of parasitic animals nematodes, tapeworms and cysticerci also apparent killing and get rid of the role. Toxicology tests showed that the toxicity of this product safe. Mouse oral LD50 greater than 800mg/kg, the canine oral maximum tolerated dose of 400mg/kg more. Can occur when the drug has no effect on the reproductive function of male mice, female mice, no teratogenic effects in female rats and female rabbits, the application of a large dose (30mg/kg / day), fetal absorption and bone malformations.
  
  [Pharmacokinetics]
  
  This product is not soluble in water, it is slowly absorbed in the intestine. The original drug in the liver into albendazole - sulfoxide and albendazole - sulfone, former insecticidal components. This product is distributed in the body followed by liver, kidney, muscle, through the blood-brain barrier, the brain tissue has a certain concentration. Reached the peak plasma concentration of 2.5 to 3 hours after oral administration. The original drug sulfone derivatives very low concentrations in the blood, can not be measured. Albendazole - sulfoxide concentration ranging from 0.04μg/ml to 0.55μg/ml, average 0.16μg/ml. The blood half-life (t1 / 2) of 8.5 to 10.5 hours. This product and its metabolite 87% from the urine within 24 hours discharge, and 13% from the feces, no savings effect in the body.
  
  
  
  
  
  

• CAS Registry Number:

  54965-21-8

• Synonyms:

  ;Albendazole suspension;[5-(PROPYLTHIO)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER;[5-(PROPYLTHIO)BENZIMIDAZOL-2-YL]CARBAMIC ACID METHYL ESTER;(5-PROPYLSULFANYL-1H-BENZOIMIDAZOL-2-YL)-CARBAMIC ACID METHYL ESTER;ALBAZINE;ALBEN;ALBENZA;AKOS NCG1-0064;(5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester;methyl [6-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate;

• Molecular Formula:

  C₁₂H₁₅N₃O₂S

• Molecular Weight:

  265.3314

• Molecular Structure:

  

• Hazard Symbols:

   T:Toxic;
  

• Risk Codes:

  R36/37/38:;
  R61:;
  

• Safety Description:

  S26:;
  S37/39:;
  S45:;
  S53:;
  

• Company:

  Hubei Yuancheng Pharmaceutical Co., ltd     [ China ]        

• Contact:

  Lupin

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  +86-27-68886724

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  +86-27-88048077-899

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