Benazepril HCL

• Post Date:

  Jun 06,2020

• Expiry Date:

  Jun 06,2021

• Detailed Description:

  Cas No. :86541-74-4 Quantity: 1Metric Tons
  Specs:99%min
  Benazepril hydrochloride Basic information
  Product Name: Benazepril hydrochloride
  Synonyms: 1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe;cgs14824a;monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo;BenazeprilHclC24H28N205.HC1;1H-1-Benzazepine-1-acetic acid, 3-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, (3S)-;1H-1-Benzazepine-1-acetic acid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, [S-(R*,R*)]-;CGS 14824A HCl;Lotensin
  CAS: 86541-74-4
  MF: C24H29ClN2O5
  MW: 460.95
  EINECS: 630-414-2
  Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics;Heterocycles;API;SONATA
  Mol File: 86541-74-4.mol
  Benazepril hydrochloride Chemical Properties
  Melting point 188-190°C
  alpha D -141.0° (c = 0.9 in ethanol)
  storage temp. Desiccate at +4°C
  solubility DMSO: ~34 mg/mL, soluble
  form solid
  color white
  Merck 14,1031
  InChIKey VPSRQEHTHIMDQM-FKLPMGAJSA-N
  CAS DataBase Reference 86541-74-4(CAS DataBase Reference
  )Safety Information
  Safety Statements 22-24/25
  RIDADR 3077
  WGK Germany 2
  RTECS CX7065000
  HS Code 29337900
  Hazardous Substances Data 86541-74-4(Hazardous Substances Data)
  MSDS Information
  Benazepril hydrochloride Usage And Synthesis
  Description Benazepril hydrochloride, a prodrug of benazeprilat, is a long-acting angiotensionconverting enzyme (ACE) inhibitor useful in the treatment of essential hypertension. In healthy humans, it was well tolerated and showed no phmacokinetic interactions with furosemide, hydrochlorothiazide, chlorthalidone, digoxin, cimetidine, atenolol, or naproxen. Benazepril hydrochloride is under investigation as a cardiostirnulant.
  Chemical Properties Crystalline Solid
  Originator Ciba-Geigy (Switzerland)
  Uses sedative, hypnotic
  Uses Used as an antihypertensive; angiotensin converting enzyme inhibitor.
  Definition ChEBI: A hydrochloride salt resulting from the reaction of benazepril with 1 mol eq. of hydrogen chloride. It is used as a prodrug for angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
  Brand name Lotensin (Novartis);Cibacen.
  Biological Activity Non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

• CAS Registry Number:

  86541-74-4

• Synonyms:

  ;benazepril hydrochloride;[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid hydrochloride;[(3R)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid hydrochloride (1:1);

• Molecular Formula:

  C₂₄H₂₉ClN₂O₅

• Molecular Weight:

  460.95046

• Molecular Structure:

  

• Company:

  shanghai missyou chemical co.,ltd.         

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