Damnacanthal CAS NO 477-84-9

• Post Date:

  Dec 12,2016

• Expiry Date:

  Dec 12,2017

• Detailed Description:

  Damnacanthal
  Detailed Information:
  Name 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde CAS NO 477-84-9
  Synonym Damnacanthal Molecular Weight 282.34
  M.F: C16H10O5 Purity 98%min
  Appearance Orange-yellow solid Place of origin China
  Solubility Soluble to 25 mM in DMSO Certificate SGS
  Documents available COA,MSDS,NMR, HPLC Packing 1Kg/bag
  25Kg/Drum
  Shelf life 2 years Storage -20 °C, sealed, avoid light,in N2
  
  
  Description:
  Damnacanthal is an anthraquinone which acts as a p56lck tyrosine kinase inhibitor. It can be extracted from Morinda citrifolia. have long been used in traditional medicine for the treatment of cancer .
  Name 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
  Synonym Damnacanthal
  Assay ≥ 98%min
  CAS 477-84-9
  Molecular formula: C16H10O5
  Percentage Composition: C 68.09%; H 3.57%; O 28.34%
  Melting Point: Mp 218-218.5℃
  Physical Description: Orange-yellow solid
  Biological Source extracted from Morinda citrifolia.
  
  primary target p56lck autophosphorylation
  primary target IC50 17 nM against p56lck autophosphorylation
  Packaging: Packaged under inert gas
  Storage -20 °C, sealed, avoid light,in N2
  Usage A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase
  The period of validity 2 years
  
  Overview
  A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.
  A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase activity. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck over PKA and PKC and >40 fold selectivity for p56lck over EGF, c-erbB2, insulin, and the PDGF receptor tyrosine kinases. In addition, damnacanthal exhibits 7-20 fold selectivity for p56lck over pp60src and pp59fyn. Inhibition of p56lck by damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties, and to reverse the phenotype of ras-transformed cells.
  
  Application:
  It have long been used in traditional medicine for the treatment of cancer .
  
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