Dental Topical Anesthesia Drugs Articaine Hydrochloride CAS 23964-57-0
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Post Date:
Nov 20,2017
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Expiry Date:
Nov 20,2018
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Detailed Description:
Cas No. :23964-57-0
Quantity: 1000Kilograms
Specs:foil bag
Price:1 USD Kilograms
Payment Method: Western Union, money gram, t/t, bitcoin
Dental Topical Anesthesia Drugs Articaine Hydrochloride CAS 23964-57-0
Quick Details:
Product Name Aarticaine hydrochloride
Synonyms Articaine hydrochloride
Molecular Formula C13H21ClN2O3S
Molecular Weight 320.8354
CAS Registry Number 23964-57-0
EINECS 245-957-7
Boiling point 440.6°C at 760 mmHg
Flash point 220.3°C
Vapour Pressure 5.79E-08mmHg at 25°C
Product Description:
Septocaine (articane hcl and epinephrine injection) injection is a sterile, aqueous solution that contains articaine HCl 4% (40 mg/mL) and epinephrine bitartrate in an epinephrine 1: 200, 000 or epinephrine 1: 100, 000 strength. Articaine HCl is an amino amide local anesthetic, chemically designated as 4-methyl-3-[2-(propylamino)-propionamido]-2-thiophenecarboxylic acid, methyl ester hydrochloride and is a racemic mixture. Articaine HCl has a molecular weight of 320.84.
Septocaine (articane hcl and epinephrine injection) contains articaine HCl (40 mg/mL), epinephrine (1: 200, 000 or 1: 100, 000) (as epinephrine bitartrate), sodium chloride (1.6 mg/mL), and sodium metabisulfite (0.5 mg/mL). The product is formulated with a 15% overage of epinephrine. The pH is adjusted with sodium hydroxide.
Product Application:
Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor The combination of articaine can be used for local or regional anaesthesia for dental procedures. Anaesthesia begins within six minutes and lasts for an hour. The half-life of articaine is approximately 1.8 hours. It is metabolised and then mainly excreted in the urine.
COA
Items Specifications
Results
Description
White or almost white powder
Conforms
Identification
IR& HPLC
Conforms
Specific Rotation
+32°~+36°
+33.26°
Related substances
Impurity D , G≤0.3%
Conforms
Impurity A , B , C , E , F , H , I≤0.2%
Conforms
Impurity with RRT 1.23≤0.2%
Conforms
Any other impurity≤0.1%
Conforms
Total impurity≤1.2%
0.75%
Acetone
≤1.0%
Conforms
Water
≤0.2%
0.12%
Assay (by HPLC)
97.0 ~ 102%
99.05%
Particle size
90%≤10μm
Conforms
Conclusion
The results conform to EP6
Usage:
Local infiltration or nerve block anesthesia, oral submucosal injection. Take blood before injecting to check for infusion into the blood vessels, especially when the nerve block is anesthetized. The injection rate should not exceed 1ml / min.
Adults: The appropriate dose must be injected according to surgery. For general surgery, usually given the dose of 1/2 to 1 or compliance. The maximum dosage of aldicamide hydrochloride should not exceed 7mg / kg body weight.
Children over 4 years of age must use different doses depending on age, weight, and type of operation of the child. The maximum dosage of aldate hydrochloride is not more than 5mg / kg body weight. The average dose of children taking aldicaine hydrochloride can be calculated as follows: Child's weight (kg) x1.33 Elderly: Half of the adult dose is used.
Fuction
Articaine blocks nerve conduction by reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent: it has the highest affinity for the open state, an intermediate affinity for the inactivated state, and the lowest affinity for the resting state.
The degree of neuronal block is affected by the diameter of the nerve. Larger-diameter fibers (touch/pressure/ motor) require higher concentrations of local anesthetic compared with small myelinated fibers (pain afferents).Articaine is lipid soluble, highly protein-bound (94%), and has a dissociation constant (pKa) of 7.8. Articaine is an intermediate-potency, short-acting local anesthetic with a fast onset of action
Recommended Local Anesthetics Drugs
Lidocaine Base 137-58-6
Lidocaine Hydrochloride 73-78-9
Benzocaine 20~50mesh 94-09-7
Benzocaine 200mesh 94-09-7
Benzocaine Hydrochloride 23239-88-5
Procaine 59-46-1
Procaine Hydrochloride 51-05-8
Tetracaine 94-24-6
Tetracaine Hydrochloride 136-47-0
Prilocaine 721-50-6
Propitocaine Hydrochloride 1786-81-8
Bupivacaine 2180-92-9
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Pramoxine Hydrochloride 637-58-1
Dibucaine Hydrochloride 61-12-1
Articaine Hydrochloride 23964-57-0
Procainamide Hydrochloride 614-39-1
Xylazine hcl 23076-35-9
Xylazine 7361-61-7
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CAS Registry Number:
23964-57-0
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Synonyms:
Articaine hydrochloride [USAN];2-Thiophenecarboxylic acid, 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester, monohydrochloride;4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl;Articaine HCl;Articaine hydrochloride;Carticaine hydrochloride;HOE 045;HOE 40045;Methyl 4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate, monohydrochloride;Septanest;Septocaine;UNII-QS9014Q792;Ultracain;Ultracaine;2-Thiophenecarboxylic acid, 4-methyl-3-(2-(propylamino)propionamido)-, methyl ester, monohydrochloride;Methyl 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-2-thenoate monohydrochloride;methyl 4-methyl-3-[(N-propylalanyl)amino]thiophene-2-carboxylate hydrochloride (1:1);
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Molecular Formula:
C13H21ClN2O3S
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Molecular Weight:
320.8354
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Molecular Structure:
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Company:
Hengyang Desen Biotechnology Co., Ltd.
[ China ]
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Contact:
Koala
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Tel:
+86-073-48164621
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027-88608190-722
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Email:
koala@desen-nutrition.com
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