Dexamethasone

• Post Date:

  Sep 19,2017

• Expiry Date:

  Mar 18,2018

• Detailed Description:

  Cas No. :50-02-2 Dexamethasone
  
  High Purity Dexamethasone Palmitate 14899-36-6
  
  Product Details
  Basic Info.
  
  Model NO.:14899-36-6
  Other Name:Dexamethasone Palmitate
  CAS:14899-36-6
  Molecular Formula:C38h59fo6
  Molecular Weight:630.87
  Einecs:None
  Melting Point:None
  Assay:99%
  Export Markets:Global
  
  Additional Info.
  
  Trademark:Saichuang
  Packing:Skilled Packing Team Give You The Best Service
  Standard:USP, EP standard
  Origin:China
  HS Code:3003101300
  Production Capacity:500ton
  
  Product Description
  
  1. Quick Detail:
  
  Dexamethasone palmitate
  Synonyms: Dexamethasone-21-palmitate;DXM-21-palmitate;Limethason;Limethasone;Lipotalon;Palmitic acid, 21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (8CI);Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxohexadecyl)oxy]-, (11β,16α)-;Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-palmitate (6CI, 8CI)
  CAS: 14899-36-6
  MF: C38H59FO6
  MW: 630.87
  Chemical Properties Colourless Thick Oil
  Usage A corticosteroid prodrug for the treatment of eye disorders.
  Packing: 5KG/TIN or as required
  
  2. Description:
  
  Dexamethasone palmitate (DXP) is a lipophilic prodrug of dexamethasone (DXM), a potent corticosteroide used to treat a variety of ophthalmic diseases. The aim of the study was to characterize the sustained release capacity (in rabbit), efficacy (in rat and rabbit), and safety (in rabbit, cat, and minipig) of intravitreal (IVT) DXP emulsions in preclinical models.
  
  3.Application:
  
  Oil-in-water emulsions of DXP were administered by IVT injections in rats, rabbits, cats, or minipigs. Efficacy was assessed in rabbits by the inhibition of VEGF-induced vascular leakage and in rats by inhibition of laser-induced choroidal neovascularization. Concentrations of DXP and DXM in aqueous humor, vitreous, retina, choroid, and blood were determined to characterize the ocular and systemic pharmacokinetic (PK) profile. Complete ophthalmic examinations (indirect ophthalmoscopy, slit-lamp biomacroscopy, electroretinography, tonometry) were performed to assess the ocular safety of IVT DXP doses up to 2,600 μg in minipig, followed by histopathologic examinations. A validated feline model of DXM-induced elevated intraocular pressure (IOP) was used to assess the ocular hypertensive impact (i.e., the safety) of an IVT injection of DXP emulsion.
  
  Dexamethasone-17-acetate, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It often is used to replace this chemical when your body does not make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; Skin, blood, kidney, eye, thyroid, and intestinal disorders (e. G., colitis); Severe allergies; And asthma. Dexamethasone-17-acetate is also used to treat certain types of cancer.
  
  Dexamethasone-17-acetate comes as a tablet and a solution to take by mouth. Your doctor will prescribe a dosing schedule that is best for you. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Dexamethasone-17-acetate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
  
  Do not stop taking Dexamethasone-17-acetate without talking to your doctor. Stopping the drug abruptly can cause loss of appetite, upset stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss. If you take large doses for a long time, your doctor probably will decrease your dose gradually to allow your body to adjust before stopping the drug completely. Watch for these side effects if you are gradually decreasing your dose and after you stop taking the tablets or oral liquid, even if you switch to an inhalation corticosteroid medication. If these problems occur, call your doctor immediately. You may need to increase your dose of tablets or liquid temporarily or start taking them again.
  
  4. Our advantange
  
  Packing
  
  Professional packing with professional materials, and We'll give clients several Packing way to choose after you contact me through my email
  
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  Price
  
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  Payment
  
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• CAS Registry Number:

  50-02-2

• Synonyms:

  ;9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione;9-alpha-fluoro-16-alpha-methylprednisolone;9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione;(8xi,11beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;

• Molecular Formula:

  C₂₂H₂₉FO₅

• Molecular Weight:

  392.4611

• Molecular Structure:

  

• Hazard Symbols:

   Xn:Harmful;
  

• Risk Codes:

  R40:;
  

• Safety Description:

  S45:;
  

• Company:

  Hubei Yuancheng Saichuang Technology Company     [ China ]        

• Contact:

  Anna Li

• Tel:

  0086-188-72220710

• Fax:

• Email:

  anna@ycphar.com