Factory pull Mifepristone Hot Sell

• Post Date:

  Jun 29,2018

• Expiry Date:

  Dec 26,2018

• Detailed Description:

  Cas No. :84371-65-3 Quantity: 1Metric Tons
  Price:1 USD Kilograms
  Payment Method: Wertern Union, Money Gram, T/T , Bitcoin
  Basic Info:
  Name:Mifepristone
  Apearance:
  CAS:84371-65-3
  MF:C29H35NO2
  MW:429.59
  Shipment:EMS,DHL,TNT,UPS,Fedx
  Package:disguised
  Payment: Bank Transfer,Bitcoin,WU,MoneyGram
  Chemical properties Melting point 150℃. [α] D20 + 138.5 (c = 0.5, chloroform). Acute toxicity LD50 mice (g/kg):> 2.6 intraperitoneal injection.
  Use of new anti-progesterone, and anti-glucocorticoid activity, without progesterone, estrogen, androgen and anti-estrogenic activity. And progesterone receptor affinity 5 times stronger than progesterone. For anti-early pregnancy, urinary arrest by pregnancy, fetal death, such as induced labor.
  Purposes: anti-early pregnancy drug
  Production process Method 1: Starting from the 3-position ketal compound (I) of 4,9-estrodien-3,17-dione, reacting with propyne magnesium bromide Grignard reagent, introducing propynyl To give the compound (II). Followed by selective epoxidation of the 5-position olefinic bond to give the compound (III). Then, p-dimethylaminophenyl group was introduced into p-dimethylaminobenzene bromide in tetrahydrofuran containing cupric bromide-methyl sulfide complex to give compound (IV). Finally, in methanol, hydrochloric acid hydrolysis and dehydration, mifepristone. Yield 21.5%.
  Method 2: 4,9-estrodien-3,17-dione as the raw material, the 3-carbonyl protection; and then epoxidation, and then in the 17-introduction of propynyl, in the 11-bit introduction of the Dimethylaminophenyl, and finally hydrolyzed to obtain mifepristone. In contrast to Scheme 1, the reaction steps are the same only in the order of epoxidation and introduction of propynyl. The overall yield of 35% -40%.
  Welcome inquiry and trying, here is Amy serving.If more details,emails pls.
  

• CAS Registry Number:

  84371-65-3

• Synonyms:

  ;Mifepriston Dianhydride;(11R,13S,17S)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one;

• Molecular Formula:

  C₂₉H₃₅NO₂

• Molecular Weight:

  429.5937

• Molecular Structure:

  

• Company:

  Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd     [ China ]        

• Contact:

  Yu Chengzhen

• Tel:

  86-731-22290202

• Fax:

• Email:

  hnzz01@ycgmp.com