Fludarabine phosphate

• Post Date:

  Jun 06,2020

• Expiry Date:

  Jun 06,2021

• Detailed Description:

  Cas No. :75607-67-9 Quantity: 1Metric Tons
  Specs:99%min
  Product Name: Fludarabine phosphate
  Synonyms: ((2R,3S,4S,5R)-5-(6-AMINO-2-FLUORO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE;FLUDARABINE PHOSPHATE (FLUDARABINE 5''-MONOPHOSPHATE);2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine;9-(5-O-Phosphono-β-D-arabinofuranosyl)-2-fluoro-9H-purine-6-amine;F-ara-AMP;9-β-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate;Fludarabine Phosphate (300 mg);Fludarabine Phosphate(Fludara)
  CAS: 75607-67-9
  MF: C10H13FN5O7P
  MW: 365.2116842
  EINECS: 616-242-0
  Product Categories: Anti-cancer&immunity;Inhibitors;Active Pharmaceutical Ingredients;Antineoplastics;Antineoplastic;API
  Mol File: 75607-67-9.mol
  Fludarabine phosphate Chemical Properties
  Melting point 203°C(dec.)(lit.)
  alpha [α]D20 +10～+14゜(c=0.5,H2O)
  Boiling point 864.2±75.0 °C(Predicted)
  density 2.39±0.1 g/cm3(Predicted)
  RTECS UO7440900
  storage temp. -20°C
  solubility DMSO: soluble1mg/mL
  form Powder
  pka 1.86±0.10(Predicted)
  color white
  Water Solubility Soluble in DMSO or water at 5mg/ml
  Merck 14,4126
  InChIKey GIUYCYHIANZCFB-GFRUICAKSA-N
  CAS DataBase Reference 75607-67-9(CAS DataBase Reference)
  Safety Information
  WGK Germany 3
  HS Code 2934990002
  MSDS Information
  Fludarabine phosphate Usage And Synthesis
  Description Fludarabine phosphate is an antimetabolite indicated for the treatment of B cell lymphocytic leukemia. It is reportedly effective in patients refractory to other therapies. Fludarabine phosphate acts by inhibiting primer RNA synthesis. Its side effects include bone marrow suppression, anemia, thrombocytopenia and neutropenia.
  Chemical Properties White or almost white, crystalline powder, hygroscopic.
  Originator Southern Research Institute (U.S.A.)
  Uses anticonvulsant
  Definition ChEBI: A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Onc incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.
  Brand name Fludara (Berlex).

• CAS Registry Number:

  75607-67-9

• Synonyms:

  ;Fludarabin Phosphate;9-bata-D-Arabinofuranosyl-2-fluoroadenine phosphate;9-b-D-Arabinofuranosyl-2-fluoroadenine-5-(dihydrogen phosphate);2-fluoro-9-(5-O-phosphonopentofuranosyl)-9H-purin-6-amine;2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine;9-beta-arabinofuranosyl-2-fluoroadenine-5'-phosphate;2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine;9-β-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate;

• Molecular Formula:

  C₁₀H₁₃FN₅O₇P

• Molecular Weight:

  365.2117

• Molecular Structure:

  

• Company:

  shanghai missyou chemical co.,ltd.         

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