Hydroxyethyl starch 130/0.4
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Post Date:
Jan 26,2025
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Expiry Date:
Apr 26,2025
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Detailed Description:
Cas No. :9005-27-0
Quantity: 500kg
Price:60.3 USD Kilograms
Payment Method: L/C/. T/T
Character:
This product is a white or almost white powder, odorless and insipidity with moisture absorption freely soluble in hot water, practically insoluble in methane acetone trichloromethane.
Pharmacological Actions
Hydroxyethyl starch (130/0.4) 6% is a synthetic colloid for use in plasma volume replacement. The plasma expansion effects of the product are determined by its mean molecular weight (130kDa), the molar substitution by hydroxyethyl groups (0.4) on glucose units of the starch, the pattern of hydroxyethyl substitution (C2/C6 ratio) of approximately 9:1, and the concentration (6%), as well as the dosage and infusion rate.1. The 130/0.4 designation refers to the molecular weight and molar substitution characteristic of this formulation of hydroxyethyl 6% starch. In general, the higher the molar substitution and the C2/C6 ratio, the slower the starch is metabolized. Hydroxyethyl starch is a derivative of thin boiling waxy corn starch, which mainly consists of a glucose polymer (amylopectin) predominantly, composed of alpha-1-4-connected glucose units with several alpha-1-6-branches. Substitution of hydroxyethyl groups on the glucose units of the polymer reduces the normal degradation of amylopectin by alphaamylase in the body. The low molar substitution (0.4) is the main pharmacological determinant for the beneficial effects of this product on pharmacokinetics, intravascular volume, and hemodilution.
After isovolemic exchange of blood with 500mL hydroxyethyl starch (130/0.4) 6% in healthy volunteers, blood volume was maintained for at least 6 hours.1 The volume expansion effects of hydroxyethyl starch 6% 130/0.4 (voluven) has been compared with that of hydroxyethyl starch (670/0.75) 6% (Hextend) in 20 volunteers bled 10% of their total blood volume in a randomized, double-blind study.
Packing
25kg/ barrel
Storage
Voluven should be stored at room temperature (15 to 25°C; 59 to 77°F) and protected from freezing
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CAS Registry Number:
9005-27-0
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Synonyms:
;Starch,2-hydroxyethyl ether;2-hydroxyethyl 2,3,4,6-tetrakis-O-(2-hydroxyethyl)-α-D-glucopyranoside - α-D-glucopyranose (1:1);
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Molecular Formula:
C22H44O17
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Molecular Weight:
580.5746
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Molecular Structure:
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