Metoclopramide

• Post Date:

  Dec 07,2018

• Expiry Date:

  Dec 07,2019

• Detailed Description:

  Cas No. :364-62-5 Clinical data
  
  
  Pronunciation
  /ˌmɛtəˈklɒprəmaɪd/
  
  
  Trade names
  Primperan, Reglan, others[1]
  
  
  AHFS/Drugs.com
  Monograph
  
  
  MedlinePlus
  a684035
  
  
  License data
  
  
  
  US FDA: Metoclopramide
  
  
  
  
  
  Pregnancy
  category
  
  
  
  AU: A
  US: B (No risk in non-human studies)
  
  
  
  
  
  
  
  
  Routes of
  administration
  By mouth, intravenous, intramuscular
  
  
  ATC code
  
  
  
  A03FA01 (WHO)
  
  
  
  
  
  Legal status
  
  
  Legal status
  
  
  
  AU: S3 (Pharmacist only)
  CA: ℞-only
  UK: POM (Prescription only)
  US: ℞-only
  
  
  
  
  
  Pharmacokinetic data
  
  
  Bioavailability
  80±15% (by mouth)
  
  
  Metabolism
  Liver
  
  
  Biological half-life
  5 h to 6 h
  
  
  Excretion
  70–85% kidney, 2% faecal
  
  
  Identifiers
  
  
  
  
  IUPAC name[show]
  
  4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide
  
  
  
  
  
  CAS Number
  
  
  
  364-62-5 Y
  
  
  
  
  
  PubChem CID
  
  
  
  4168
  
  
  
  
  
  IUPHAR/BPS
  
  
  
  241
  
  
  
  
  
  DrugBank
  
  
  
  DB01233 Y
  
  
  
  
  
  ChemSpider
  
  
  
  4024 Y
  
  
  
  
  
  UNII
  
  
  
  L4YEB44I46
  
  
  
  
  
  KEGG
  
  
  
  D00726 Y
  
  
  
  
  
  ChEBI
  
  
  
  CHEBI:107736 Y
  
  
  
  
  
  ChEMBL
  
  
  
  CHEMBL86 Y
  
  
  
  
  
  ECHA InfoCard
  100.006.058
  
  
  Chemical and physical data
  
  
  Formula
  C14H22ClN3O2
  
  
  Molar mass
  299.80 g/mol
  
  
  3D model (Jmol)
  
  
  
  Interactive image
  
  
  
  
  
  Melting point
  147.3 °C (297.1 °F)
  
  
  
  
  SMILES[show]
  
  
  Clc1cc(c(OC)cc1N)C(=O)NCCN(CC)CC
  
  
  
  
  
  
  
  
  InChI[show]
  
  
  InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19) Y
  
  
  Key:TTWJBBZEZQICBI-UHFFFAOYSA-N Y
  
  
  
  
  
  
  (verify)
  
  
  Metoclopramide is a medication used mostly for stomach and esophageal problems.[2] It is commonly used to treat and prevent nausea and vomiting, to help with emptying of the stomach in people with delayed stomach emptying, and to help with gastroesophageal reflux disease.[3] It is also used to treat migraine headaches.[4]
  Common side effects include: feeling tired, diarrhea, and feeling restless. More serious side effects include: movement disorder like tardive dyskinesia, a condition called neuroleptic malignant syndrome, and depression.[3] It is thus rarely recommended that people take the medication for longer than twelve weeks.[3] It is pregnancy category B in the United States and category A in Australia, meaning no evidence of harm has been found after being taken by many pregnant women.[3][5] It belongs to the group of medications known as dopamine-receptor antagonists.[3]
  In 2012, metoclopramide was one of the top 100 most prescribed medications in the United States.[6] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[7] It is available as a generic medication.[3] The wholesale cost in the developing world as of 2014 is 0.003 to 0.08 USD per pill.[8] In the United States a month worth of medication is generally less than 25 USD.[9]

• CAS Registry Number:

  364-62-5

• Synonyms:

  ;4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide;4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide;Metoclopramide anhydrous;

• Molecular Formula:

  C₁₄H₂₂ClN₃O₂

• Molecular Weight:

  299.7964

• Molecular Structure:

  

• Company:

  Jinan Chenghishaungda Chemical Co.,LTD     [ China ]        

• Contact:

  Allen

• Tel:

  15689693073

• Fax:

  0531-58897032

• Email:

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