N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate

• Post Date:

  Jun 07,2016

• Expiry Date:

  Dec 04,2016

• Detailed Description:

  Cas No. :341031-54-7 CAS: 341031-54-7
  MF: C22H27FN4O2.C4H6O5
  MW: 532.566
  EINECS:
  Product Categories: APIs;Heterocycles;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals;Tyrosine Kinase Inhibitors;SU-11248
  Mol File: 341031-54-7.mol
  
  
  
  N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate Chemical Properties
  mp 189-191°C
  storage temp. Store at +4°C
  CAS DataBase Reference 341031-54-7(CAS DataBase Reference)
  Usage Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
  Usage Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit
  Usage A multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Antineoplastic.
  Biological Activity Potent, ATP-competitive VEGFR, PDGFR β and KIT inhibitor (K i values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR β and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.
  
  CAS: 341031-54-7
  MF: C22H27FN4O2.C4H6O5
  MW: 532.566
  EINECS:
  Product Categories: APIs;Heterocycles;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals;Tyrosine Kinase Inhibitors;SU-11248
  Mol File: 341031-54-7.mol
  
  
  
  N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate Chemical Properties
  mp 189-191°C
  storage temp. Store at +4°C
  CAS DataBase Reference 341031-54-7(CAS DataBase Reference)
  Usage Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
  Usage Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit
  Usage A multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Antineoplastic.
  Biological Activity Potent, ATP-competitive VEGFR, PDGFR β and KIT inhibitor (K i values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR β and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.
  

• CAS Registry Number:

  341031-54-7

• Synonyms:

  ;SUNITINIB MALEATE;1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)- (5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4- dimethyl-, (2S)-hydroxybutanedioate (1:1);Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2- (diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H- indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3- carboxamide (1:1);N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate;(2S)-2-hydroxybutanedioic acid - N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1);2-hydroxypentanedioic acid - N-[2-(diethylamino)ethyl]-2,4-dimethyl-5-[(Z)-(5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxamide (1:1);Sunitinib Mablate;

• Molecular Formula:

  C₂₈H₃₈N₄O₇

• Molecular Weight:

  542.62392

• Molecular Structure:

  

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  Yuan Cheng Saichuang Ltd. Co.     [ China ]        

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