Natural Nootropics NSI - 189 Powder AFA CAS No. 1270138-40-3 NSI189

• Post Date:

  Nov 20,2017

• Expiry Date:

  Nov 20,2018

• Detailed Description:

  Cas No. :1270138-40-3 Quantity: 1000Kilograms
  Specs:foil bag
  Price:1 USD Kilograms
  Payment Method: Western Union, money gram, t/t, bitcoin
  Natural Nootropics NSI - 189 Powder AFA CAS No. 1270138-40-3 NSI189
  
  Basic info.
  
  Product Name: NSI-189
  Synonyms: NSI-189;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl];[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]NSI189;NSI-189 [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl];NSI-189, >=98%;(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]
  CAS: 1270138-40-3
  MF: C22H30N4O
  MW: 366.4998
  EINECS: -0
  Mol File: 1270138-40-3.mol
  
  
  
  Description
  
  NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro. In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.
  
  The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer's disease, and major depressive disorder (MDD).
  
  
  
  Application
  
  NSI-189 successfully completed a phase I clinical trial for MDD in 2011, where it was administered to 41 healthy volunteers. A phase Ib clinical trial for treating MDD in 24 patients started in 2012 and completed in July 2014, with results published in December 2015. Neuralstem is now preparing to initiate phase II clinical studies for MDD in the first quarter of 2016, with results expected in the second half of 2017. In the two clinical studies conducted thus far, NSI-189 has shown statistically significant effectiveness in reducing depressive symptoms, has been found to be safe and well-tolerated (with no major adverse effects observed), and has been found to improve cognitive deficits in depressed patients. In addition to MDD, Neuralstem intends to pursue clinical development of NSI-189 for a variety of other neurological conditions, including traumatic brain injury, Alzheimer's disease, post-traumatic stress disorder, stroke, and natural cognitive and memory decline in aging.
  
  
  How NSI-189 works
  
  This drug was developed to address three important aspects of depression including hippocampal volume, neurogenesis and neurotransmission. NSI-189 increases the volume within the hippocampus. In so doing, hippocampal volume and healthy brain cell density is increased thereby improving mod and cognitive performance. Aside from increasing hippocampal volume, the drug also improves neuronal cell functionality. It works it promoting healthy neuronal cell growth whilst repair damaged areas in the brain.
  
  
  Dosing NSI-189
  
  Phase 1A tested escalating doses of the neurogenic compound NSI-189 in healthy patients, 1B tested the safety of escalating doses in 24 depressed patients over the course of 28 days . During phase 1B patients were administered 40 mg per day, and 80 mg per day, and at the highest dose 120 mg per day. No serious adverse events occurred during the time of the study and the drug was well tolerated. Reduction in cognitive and depressive symptoms were observed across all measures for the two lower doses 40 mg/day and 80 mg/day but not for the highest dose 120 mg/day .
  
  
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  Reference List of Available Nootropics:
   
  CAS Product Name Other Name
  135463-81-9 Coluracetam BCI-540
  62613-82-5 Oxiracetam ISF 2522
  72432-10-1 Aniracetam Draganon
  59776-89-5 Piracetam  
  72869-16-0 Pramiracetam CI-879
  157115-85-0 Noopept GVS-111
  15180-02-6 Amfonelic Acid AFA
  314728-85-3 Sunifiram DM-235
  1270138-40-3 NSI-189 NSI189
  51352-87-5 PRL-8-53  
  314728-85-3 Unifiram DM-232
  22503-72-6 IDRA-21  
  
  

• CAS Registry Number:

  1270138-40-3

• Company:

  Hengyang Desen Biotechnology Co., Ltd.     [ China ]        

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  Koala

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