Pirfenidone

• Post Date:

  Jan 09,2018

• Expiry Date:

  Jul 08,2018

• Detailed Description:

  Cas No. :53179-13-8 Quantity: mass in stockKilograms
  Specs:white powder
  Price:negotiable USD Kilograms
  Payment Method: T/T, Western Union,Moneygram and Bitcoin.
  Description:
  
  Pirfenidone is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.
  
  Pirfenidone (PFD) is a novel kind of pyridine ketones which has a broad-spectrum anti-fibrotic effect, being able to prevent and reverse the formation of fibrosis and scar. It entered into market in Shionogi, Japan in 2008 and has been approved by the US food and Drug Administration. It is the first drug which has gone through phase III clinical trials (including repeating, randomized, and placebo-control) which has demonstrates its effectiveness in treating idiopathic pulmonary fibrosis (IPF); moreover, the drug has relative good efficacy in treating some fibrotic diseases such as renal interstitial fibrosis and liver fibrosis. Furthermore, it is also widely applied in the phase II clinical study in kidney disease (focal segmental glomerulosclerosis), hypertrophic cardiomyopathy, adult type I neurofibromatosis, youth I type of neurofibromatosis and plexiform neurofibromas, diabetes together with kidney disease.
  
  
  Applications:
  
  In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis .
   
  Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also.
   
  Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
  
  
  Functions:
  
  1. Idiopathic pulmonary fibrosis degeneration
  
  2. Liver Fibrosis
  
  3. Renal fibrosis disease
  
  4. Multiple Sclerosis
  
  5. Myocardial fibrosis
  
  6. Neoplastic diseases: neurofibroma, leiomyoma, and malignant gliomas.
  
  7. Prevention of fibrosis after the organ transplant.
  
  8. Rheumatoid arthritis.

• CAS Registry Number:

  53179-13-8

• Synonyms:

  ;5-Methyl-1-phenyl-2-(1H)-pyridone;5-methyl-1-phenylpyridin-2(1H)-one;

• Molecular Formula:

  C₁₂H₁₁NO

• Molecular Weight:

  185.2218

• Molecular Structure:

  

• Hazard Symbols:

   Xn:Harmful;
  

• Risk Codes:

  R22:;
  

• Safety Description:

  S36:;
  

• Company:

  Hengyang Desen Biotechnology Co., Ltd.     [ China ]        

• Contact:

  ava

• Tel:

  86-18908446905

• Fax:

• Email:

  ava@ycgmp.com