Sindose

• Post Date:

  Aug 12,2014

• Expiry Date:

  Aug 12,2015

• Detailed Description:

  Cas No. :3366-95-8 Quantity: 10Kilograms
  Specs:Sindose,Secnidazole,3366-95-8
  Price:1-10000 USD Kilograms
  Payment Method: T/T,L/C.WU
  Product Name： Secnidazole
  Other names: Flagentyl, Sindose, Secnil
  Category: pharmaceutical raw material bulk drugs api
  CAS NO: 3366-95-8
  M.F.: C7H11N3O3.1/2H20
  Quality standard: YBH12562008;
  Edition: CP
  Applicable category:Antianaerobic-microbacterial drug,antitrichomonal agent ;
  Finished dosage: Secnidazole capsules, Secnidazole tablets ;
  Appearance: almost white to pale yellow crystalline powder,odourless,bitter flavor;
  Freely soluble in ethanol, chloroform and propanol,sparingly soluble in 0.1mol/l hydrochloric acid, slightly soluble in water;
  Assay: not less than 99% on anhydrous basis;
  Loss on drying: 4.5 %~6%
  Appearance of solution: clear and colorless;
  Melting point: 74~78℃;
  Related impurities:The peak area of total impurities ≤1%;
  Heavy metal: ≤10 ppm;
  Packing: 10 kg/drum
  Advantage: High purity, Low heavy metal, Low related impurities, GMP certificate, Profession
  Activity & Sevice: pharmaceuticals looking for distributors, wholesale pharmaceutical generic drugs, provide lab testing service pharmaceutical
  
  Product Introduction: Secnidazole is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported.It has also been tested against Atopobium vaginae.
  
  Secnidazole is structurally related to the commonly used 5-nitroimidazoles metronidazole and tinidazole. These drugs share a common spectrum of activity against anaerobic micro-organisms and they appear particularly effective in the treatment of amoebiasis, giardiasis, trichomoniasis and bacterial vaginosis. Secnidazole is rapidly and completely absorbed after oral administration and has a longer terminal elimination half-life (approximately 17 to 29 hours) than commonly used drugs in this class. In patients with intestinal amoebiasis or giardiasis, clinical or parasistological cure rates of 80 to 100% are achieved after treatment with a single dose of secnidazole 2 g (30 mg/kg in children), similar to the response rates achieved with multiple dosage regimens of metronidazole or tinidazole. Patients with hepatic amoebiasis appears to respond well to 5- to 7-day therapy with secnidazole, but the efficacy of this drug regimen requires further evaluation in larger numbers of patients. After administration of a single dose of secnidazole, parasitological eradication was achieved in approximately 92 to 100% of patients with urogenital trichomoniasis. Patients with bacteria vaginosis respond at least as well to a single dose of secnidazole as to single-dose tinidazole, or single- or 7-day treatment with metronidazole; clinical improvement and/or microbiological evidence of cure was attained in approximately 59 to 96% of patients. In the clinical trials reviewed, secnidazole was well tolerated; most adverse events were gastrointestinal in nature and did not require treatment intervention or withdrawal from therapy.
  
  In summary, available evidence suggests that secnidazole is as efficacious as other 5-nitroimidazole drugs in the treatment of protozoal infections and bacterial vaginosis. The convenience and ease of administration associated with single-dose therapy, combined with a good tolerability profile, make secnidazole a suitable option to other single-dose treatments and an attractive alternative to multiple dosage regimens with other drugs in this class.
  
  
  
  
  
  
  

• CAS Registry Number:

  3366-95-8

• Synonyms:

  ;alpha,2-dimethyl-5-nitro-1h-imidazole-1-ethanol;1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol;

• Molecular Formula:

  C₇H₁₁N₃O₃

• Molecular Weight:

  185.1805

• Molecular Structure:

  

• Company:

  Hunan Dinuo Pharmaceuical Co.,Ltd     [ China ]        

• Contact:

  Cuckoo Deng,Jennifer Wang

• Tel:

  +86-0731-88280100-8561/2

• Fax:

  +86-0731-88280157

• Email:

  sales@cphi-dinuo.com