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Sitagliptin Phosphate 654671-78-0

  • Post Date:

    Dec 17,2024
  • Expiry Date:

    Dec 17,2025
  • Detailed Description:

    Cas No. :654671-78-0 Quantity: 500Kilograms
    Specs:Assay: 98.0%~102.0%
    Payment Method: L/C; T/T
    Sitagliptin Phosphate
    CAS 654671-78-0
    Molecular Formula: C16H18F6N5O5P
    Molecular Weight: 505.31
    Synonyms: (2R)-4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate salt; MK 0431;
    Package: less than 3kg, moisture-proof plastic bag inside, alu-foil bag outside; 3kg~25kg, moisture-proof plastic bag inside, carton outside.
    Function: Sitagliptin is an oral antihyperglycemic (antidiabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. Sitagliptin was approved by the U.S. Food and Drug Administration (FDA) on October 17, 2006, and is marketed in the US as Januvia by Merck & Co.
    Items Specification
    Appearance White or off white powder
    Solubility Easy to dissolve in water
    Identification HPLC
    IR
    Water ≤1.0%
    Melting point 203.0℃~205.0℃
    Heavy metals ≤20ppm
    Residue on ignition ≤0.1%
    Chiral impurities ≤1.0%
    Specific rotation -18.0°~-23.0°(C=1,water)
    Related impurities Total impurity≤1.0%
    Assay 98.0%~102.0%
    Conclusion Comply with In-house standard.
  • CAS Registry Number:

    654671-78-0
  • Synonyms:

    ;sitagliptin phosphate intermediates;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate;(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-phosphate;
  • Molecular Formula:

    C16H18F6N5O5P
  • Molecular Weight:

    505.3088
  • Molecular Structure:

    654671-78-0 sitagliptin phosphate
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