Topiramate(CAS No. 97240-79-4)

• Post Date:

  Sep 02,2013

• Expiry Date:

  Sep 09,2013

• Detailed Description:

  
  Name:Topiramate
  CAS Registry number:97240-79-4
  Synonyms:McN-4853;Epitomax;
  2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranos sulfamate;
  a-D-Fructopyranose,2,3:4,5-bis-O-(1-methylethylidene)-,sulfamate;
  Tipiramato [Spanish];Topamax;
  Topiramate [USAN:BAN:INN]
  more details can be found on the page:http://www.guidechem.com/reference/dic-28727.html.
  
  
  Usage:Used as an anticonvulsant
  Biomedical Effects and Toxicity
  Biological Activity:
  Anticonvulsant. Antagonizes GluR5 kainate receptors (IC 50 = 0.46 μ M), acts as a positive allosteric modulator of GABA A receptor-mediated currents, inhibits Na v channels (IC 50 = 48.9 μ M) and inhibits L-type Ca 2+ channels. Also inhibits carbonic anhydrase (CA) (K i values are 0.1 and 0.2 μ M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.

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  run-biotech Co., Ltd.     [ China ]        

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