Vecuronium bromide

• Post Date:

  Jun 06,2020

• Expiry Date:

  Jun 06,2021

• Detailed Description:

  Cas No. :50700-72-6 Quantity: 1Metric Tons
  Specs:99%min
  Vecuronium bromide Basic information
  Description References
  Product Name: Vecuronium bromide
  Synonyms: norcuron;VECURONIUM BROMIDE;VECRONIUM BROMIDE;(+)-1-(3,17-diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium bromide;VECURONIUM BROMIDE, USP STANDARD;VECURONIUM BROMIDE, RELATED COMPOUND A3ALPHA, 17BETA-DIACETYL-OXY-2BETA, 16BETA-BISPIPERIDINYL-5ALPHA-ANDROSTAN USP STANDARD;VECURONIUM BROMIDE, EP;VECUROMIUM BROMIDE
  CAS: 50700-72-6
  MF: C34H57BrN2O4
  MW: 637.73138
  EINECS: 256-723-9
  Product Categories: Pharmaceutical material and intermeidates;Organics;Neuromuscular blocking agent;Steroids;Acetylcholine receptor;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;API;CAMPRAL
  Mol File: 50700-72-6.mol
  Vecuronium bromide Chemical Properties
  Melting point 227-229°C
  alpha +30.5～+35.0゜(D/20℃)(c=0.5,dil.HCl)
  storage temp. -20°C Freezer
  solubility Slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in acetonitrile and in anhydrous ethanol.
  form neat
  Merck 14,9941
  BRN 4837308
  InChIKey VEPSYABRBFXYIB-PWXDFCLTSA-M
  CAS DataBase Reference 50700-72-6(CAS DataBase Reference)
  Safety Information
  Hazard Codes Xi,Xn
  Risk Statements 36/37/38-22
  Safety Statements 26-37/39
  WGK Germany 3
  RTECS TN4875000
  HS Code 2933399090
  Toxicity LD50 in mice: 0.061 mg/kg i.v. (Buckett)
  Vecuronium bromide Usage And Synthesis
  Description Vecuronium bromide (Brand name: Norcuron) is a drug which can be supplied to general anesthesia to keep skeletal muscle relaxation during the surgery or mechanical ventilation. It can also be used to help with endotracheal intubation. It has rapid onset (within 4 minutes) and has its effect last for 4 hour. Its mechanism of action is through competitively binding to the nicotinic cholinergic receptors, further antagonizing the opportunity for acetylcholine from binding to the nicotinic receptor at the postjunctional membrane of the myoneural junction. This process prevents the depolarization and the release of calcium ions, stopping muscle contraction and help muscle relaxation.
  References https://en.wikipedia.org/wiki/Vecuronium_bromide
  https://www.drugbank.ca/drugs/DB01339
  Chemical Properties White Solid
  Uses alcohol antagonist
  Uses An aminosteroid, competitive neuromuscular blocker agent.
  Definition ChEBI: The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium su stituents.
  Brand name Norcuron (Organon).
  Biological Functions Vecuronium bromide (Norcuron) is chemically identical to pancuronium except for a tertiary amine in place of a quaternary nitrogen. However, some of the drug will exist as the bisquaternary compound, depending on body pH. Vecuronium has a moderate onset of action (2.4 minutes) and a duration of effect of about 50 minutes. Like pancuronium, it does not block ganglia or vagal neuroeffector junctions, does not release histamine, and is eliminated by urinary excretion.
  General Description Vecuronium bromide, 1-(3 ,17 -dihydroxy-2 -piperidino-5 -androstan-16 -yl)-1-methylpiperidinium bromide diacetate (Norcuron), is themonoquaternary analog of pancuronium bromide. It belongsto the class of nondepolarizing neuromuscular blockingagents and produces effects similar to those of drugs in thisclass. It is unstable in the presence of acids and undergoesgradual hydrolysis of its ester functions in aqueous solution.Aqueous solutions have a pH of about 4.0.
  Clinical Use Vecuronium Bromide is usedmainly to produce skeletal muscle relaxation during surgeryand to assist in controlled respiration after general anesthesiahas been induced.
  Veterinary Drugs and Treatments Vecuronium is indicated as an adjunct to general anesthesia to produce muscle relaxation during surgical procedures or mechanical ventilation and to facilitate endotracheal intubation. It causes very minimal cardiac effects and generally does not cause the release of histamine.

• CAS Registry Number:

  50700-72-6

• Synonyms:

  ;Norcuron;(+)-1-(3,17-Diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium bromide;(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-(piperidin-1-yl)androstane;(3alpha,5alpha)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-piperidin-1-ylandrostane bromide;(2beta,3alpha,8xi,9xi,14xi,16beta,17beta)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-piperidin-1-ylandrostane bromide;

• Molecular Formula:

  C₃₄H₅₇BrN₂O₄

• Molecular Weight:

  637.7314

• Molecular Structure:

  

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