pharmaceutical grade Low substituted hydroxypropylcellulose (L-HPC)/Klucel as a binder/binding agent

Post Date:
Mar 22,2016
Expiry Date:
Sep 18,2016
Detailed Description:
Cas No. :9004-64-2 Quantity: 10Metric Tons
L-HPC is available in different particle sizes, which make the material suitable for tableting, "anti-capping" or pelletization and extrusion.
Conforms to standard USP27.
Text USP27
Hydroxy proroxy assay% 7.0-16.0
Loss on drying% ≤5.0
Heavy metals ≤10ppm
Residue on ignition% ≤0.5
Chloride% ≤0.36
Arsenic ≤3ppm

Application:
HPC is used in pharmaceutical industry as cohesive agent, pill coating, and low release agent;
1. mainly as disintegrating agent and adhesive agent for solid preparations. It can make tablet easier to disintegrate and improve hardness and glossiness of the tablet.
2. To improve the formability, brittleness and evacuation as well as improve hardness and accelerate tablet disintegrate for some big fragile tablets with high elasticity
3. L-HPC is useful as disintegrant with low chemical side-reactivity, for direct compression and pelletization (fast disintegrating pellets).
CAS Registry Number:
9004-64-2
Synonyms:
;Cellulose, 2-hydroxypropyl ether;Hydroxypropyl cellulose, Average M.W. 100.000;Klucel;1-[(5R)-3,4-bis(2-hydroxypropoxy)-6-(2-hydroxypropoxymethyl)-5-[(2S)-3,4,5-tris(2-hydroxypropoxy)-6-(2-hydroxypropoxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxypropan-2-ol;
Molecular Formula:
C₃₆H₇₀O₁₉
Molecular Weight:
806.9296
Molecular Structure:
Safety Description:
S24/25:;

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