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p-Toluenesulfonamide

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  Post Date: Oct 11,2018
  Expiry Date: Oct 11,2019
  Detailed Description: Cas No. :70-55-3 Payment Method: T/T D/A D/P L/C
p-Toluenesulfonamide
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P-TOLUENESULFONAMIDE
CAS N°: 70-55-3
Identifiers, Physical and Chemical properties 1
CAS Number : 70-55-3
End Point : IDENTIFIERS, PHYSICAL AND CHEMICAL PROPERTIES
Substance
Chemical Name : Benzenesulfonamide, 4-methyl-
Common Name : p-Toluenesulfonamide
RTECS Number : XT5075000
Properties & Definitions
Molecular Formula : C7H9NO2S
Molecular Weight : 171.23
Melting Point : 137.5C
Boiling Point : 221C at 10 mmHg
State : Solid
Flash Point : 202C (c-cup)
Vapour Pressure : 0.1 kPa(0.75 mmHg) at 170C
Octanol/Water Partition :
Coefficient
0.84 at 25C
Water Solubility : 3.2 g/L at 25C
Impurities : =<4%. o-Toluenesulfonamide, sodium chloride, ammonium chloride.
General Comments : Non-volatile. Stable in neutral, acidic or alkaline solutions.
p-Methylbenzenesulfonamide 4-Methylbenzenesulfonamide
Toluene-4-sulfonamide Toluene-p-sulfonamide
Tolylsulfonamide p-Tolylsulfonamide
Tosylamide p-Tosylamide
4-MBSA
Synonyms
log Pow =
SIDS INITIAL ASSESSMENT
PRESENTLY OF LOW CONCERN
4-Methylbenzenesulfonamide is non-volatile stable solid, and the production volume is ca. 1700 tonnes and
1000 tonnes for 1985 and 1991, respectively, in Japan. Canada and Sweden imported less than 100 kg in
1992. This chemical is used mainly as intermediate for pesticides and drugs in closed system, but is used as
additive to outdoor paints in Sweden. This chemical is stable in neutral, acidic or alkaline solutions, and is
classified as "not readily biodegradable".
The fact that the chemical is slightly toxic to algae, but non-toxic to fish and daphnids, implies the environmental
risk presumably to be low. The PEC is lower than the MTC.
The chemical showed no genotoxic effects, and LOAEL for repeated dose toxicity was 120 mg/kg/day and
NOAEL for reproductive toxicity was 300 mg/kg/day. Estimated dose of low concern (EDLC) was calculated as
0.024 mg/kg/day and 0.6 mg/kg/day for repeated dose toxicity and reproductive toxicity, respectively. Daily
intake of the chemical was estimated as 4.36-E-5 mg/day from calculation using MNSEM 145I exposure model.
Therefore, health risks from general environment presumably to be low because estimated human exposure
(EHE) level of this chemical is lower than the EDLC.
In conclusion, although 4-methylbenzenesulfonamide is persistent and toxicological tests showed moderate
toxicity, no further testing is needed at present considerering its use pattern and exposure levels.
ENVIRONMENTAL EXPOSURE
Biodegradability: "not readily biodegradable"
Overall Evaluation
IRPTC Data Profile
2 Identifiers, Physical and Chemical properties
ESTIMATION OF ENVIRONMENTAL FATE, PATHWAYS AND CONCENTRATIONS
Comparison of calculated environmental concentration using several models.
Model MNSEM:
Air: 1.88E-8 ug/L; Water: 0.0203 ug/L; Soil: 2.15E-3 ug/kg; Sediment: 0.104 ug/kg
Model CHEMCAN2:
Air: 1.38E-11 ug/L; Water: 0.0203 ug/L; Soil: 1.02E-6 ug/kg; Sediment: 0.0113 ug/kg
Model CHEMFRAN:
Air: 4.22E-13 ug/L; Water: 0.0203 ug/L; Soil: 5.93E-8 ug/kg; Sediment: 0.0113 ug/kg
Model UKMODEL:
Air: 5.88E-8 ug/L; Water: 0.0202 ug/L; Soil: 3.63E-2 ug/kg; Sediment: 0.0727 ug/kg
CONSUMER EXPOSURE
In Sweden, this chemical (< 100 kg) is used as a preservative of all types of outdoor paints (one or more
formulation paints). From present information on uses, consumer exposure seems to be low because this
chemical is used mainly as raw material for synthesis of pesticides, drugs and fluorescent colorants in closed
system.
OCCUPATIONAL EXPOSURE
Processes are closed system except drying and packaging. Exposure will be considered in drying process (2.5
hour/tonne product) and packaging process (1.25 hour/tonne product). No data on work place monitoring have
been reported. Occupational exposure seems to be low.
CONCLUSION
Based upon the available information , although 4-methylbenzenesulfonamide is persistent and toxicological
tests showed moderate toxicity, no further testing is needed at present considering its exposure levels and use
pattern.
RECOMMENDATION
Continuation of data collection on exposure will be recommended.
If this chemical is used largely in consumer products in the future, long-term repeated dose (e.g. 90 days)
toxicity test may be needed, because histopathological changes of urinary bladder and thymus were observed in
combined repeat/repro. toxicity test.
Also, monitoring of this chemical in the production site may be recommended for the prevention of occupational
exposure.
IRPTC Data Profile
Production-Trade 3
CAS Number : 70-55-3
Production-Trade
Geographic Area : JPN
Chemical Name : Benzenesulfonamide, 4-methyl-
1991
Production
1000 t - P
1700 t - P
Quantity Year
1985
General Comments : These (1700 t) refer to the values for production and import levels in 1985.
References
!SIDSP*
OECD/SIDS. Screening Information Data Set (SIDS) of OECD High
Production Volume Chemicals Programme, (1994)
CAS Number : 70-55-3
Production-Trade
Chemical Name : Benzenesulfonamide, 4-methyl-
1992
Production
<100 kg - IM
Quantity Year
General Comments : Canada and Sweden imported less than 100 kg in 1992. There are no
production and no products containing the substance in Denmark and Finland.
References
!SIDSP*
OECD/SIDS. Screening Information Data Set (SIDS) of OECD High
Production Volume Chemicals Programme, (1994)
IRPTC Data Profile
4 Processes
CAS Number : 70-55-3
Chemical Name : Benzenesulfonamide, 4-methyl-
Processes
Process comments : The chemical is synthesized by reaction of p-toluenesulfonyl chloride
with ammonia. Processes are closed system except drying and
packaging.
Process
References
Secondary Reference : !SIDSP*
OECD/SIDS. Screening Information Data Set (SIDS) of OECD High
Production Volume Chemicals Programme, (1994)
IRPTC Data Profile
Uses 5
CAS Number : 70-55-3
Uses
Chemical Name : Benzenesulfonamide, 4-methyl
Use
Quantity Year
Unspecified amount used as raw material for the
synthesis of pesticides, fluorescent colorant and drugs.
Unspecified amount used as plasticizer for
thermosetting resins below 1%.
Comments
References
Secondary References : !SIDSP*
OECD/SIDS. Screening Information Data Set (SIDS) of OECD High
Production Volume Chemicals Programme, (1994)
CAS Number : 70-55-3
Uses
Geographic Area : SWE
Chemical Name : Benzenesulfide, 4-methyl-
Use
Quantity Year
Unspecified amount used in a preservative which is
mainly used as an additive to all types of outdoor
paints (one or more formulation paints).
Comments
References
Secondary References : !SIDSP*
OECD/SIDS. Screening Information Data Set (SIDS) of OECD High
Production Volume Chemicals Programme, (1994)
IRPTC Data Profile
6 Concentration
Species/strain/system : Air, water, soil, sediment.
AIR
WATER
SOIL
Test Subject
Organism Medium Specification Lifestage Sex
CAS Number : 70-55-3
Chemical Name : Benzenesulfonamide, 4-methyl-
End Point : CONCENTRATION
Study
Geographic Area : JPN
Test method :
description

  CAS Registry Number:

70-55-3
  Synonyms: ;PASAM;p-Toluenesulphonamide;Para-Toluene Sulfonamide;Ortho Para-Toluene Sulfonamide;P-TOLUENE SULFONAMIDE;P-toluene sulfonylamine;Photoinitiator-6105l;Toluene-4-sulphonamide;4-Toluene sulfonamide;4-Methylbenzenesulfonamide;PTSA;Toluene-4-sulfonamide;p-Toluenesulfonylamide;P-toluene Sulfonamine(PTSA);
  Molecular Formula: C7H9NO2S
  Molecular Weight: 171.2169
  Molecular Structure: 70-55-3 p-Toluenesulfonamide
  Hazard Symbols:  Xi:Irritant;
  Risk Codes: R36:;
  Safety Description: S26:;

  Company: Sinoright International Trade Co. Ltd.     [ China ]          
  Contact: Harry Du
  Tel: 0086-411-86596755 39210844 130
  Fax: 0086-411-86596060 39210855
  Email: harry.du@sinoright.net
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