AJ Organica is a bio/chem-technology company developing advanced technologies with initial efforts in Chemical and Biochemical Sciences. The products of the company are high-value intermediates, processes and custom developed unique process solutions for pharmaceutical and specialty chemical industry in high impact areas such as Nanotechnology.Our Request a molecule program provides a method to call for materials at no up front cost to customer. AJ Organica is an affiliate of YewSavin, (USA) Inc., and a world class R&D synthesis lab located in India providing cost effective access to highly skilled synthetic chemists, and laboratory, for small molecule drug discovery. AJ Organica currently has setup to perform advanced research in organic synthesis and purification experiments from 1 ml to 20 Liters. A laboratory set up of 2000 square feet is equipped with flash chromatography, dry reaction set up, fume hood, solvent stills, rotary evaporators, microwave reaction equipment, TLC and detection systems. The lab is equipped with modern electronics and communication computers with video conferencing with the world. The facility has 10 Kw backup power sources for uninterrupted operation of critical experiments. We have finished three five-step routes with US partners, using efficient video conferencing and communications. The lab under construction has benches for 15 chemists, 60 running ft of fume hood space, and supporting office and storage space. We have on call access to leased Agilent HPLC, high field NMR, FT-IR, UV-VIS, CI EI MS, and elemental analysis equipment, and access to a microbiology laboratory. We currently have two Ph.D. Scientists in advisory role, with four M.Sc. Organic chemists, engaged in advanced materials synthesis, and a Ph.D. biochemist is engaged in enzymatic reactions for nucleoside preparation (synthetic biology). Two Ph.D. advisors with fifteen years of experience and combined experience of 30 publications and 70 patents are available on call. Current projects include GSK-3 inhibitors, Phthalocyanines, Napthalocyanines, Porphyrins, and Coumarins, and nucleoside analogs for biochemical and electronics applications. We have successfully finished multi-step syntheses using Bromination, Grignard reaction, Suzuki coupling, Amidation, and Esterification reactions. We have finished six target molecules of five steps or more with 99.9+% HPLC purity, and scaled to 250g, using our crystallization expertise. Materials such as Porphyrins, Cyanines and Naphthalocyanines, Coumarins and Nucleoside analogs are special areas of expertise. Some of the current project include Curmin analogs for Alzeheimer's disease, and GSK-3 inhibitor syntheses. We have libraries of plant extracts based on Aurvedic Treatments under scrutiny for further study. We will have room to take on an assignment shortly since one of the projects is ready for transfer getting scaled to 20L. World class trained staff, laboratory, and real life communication access at very reasonable cost presents unique features and mutually rewarding opportunities for collaboration in discovery sciences. We have on demand access to antibody, biochemistry, toxicology and microbiology facilities, due to our alliance with other labs, and efforts underway to set up a healthcare / clinical trials center. |